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Tbio
ADM
ADM

Protein Summary
Description
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278175
  • ENSP00000278175
  • ENSG00000148926
  • ENST00000525063
  • ENSP00000435124
  • ENST00000528655
  • ENSP00000436607

Symbol
  • AM
  • AM
  • PAMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
1
small molecule perturbation
1
PubMedID
0.99


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2035.74   (req: < 5)
Gene RIFs: 284   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2035.74   (req: >= 5)
Gene RIFs: 284   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenomedullin
VGNC:3228
451021
Macaque
adrenomedullin
703305
Mouse
MGI:108058
11535
Rat
RGD:2047
25026
Dog
adrenomedullin
VGNC:37660
403817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenomedullin
Macaque
adrenomedullin
Mouse
Rat
Dog
adrenomedullin
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35318-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (75)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (54)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (177)
1 – 10 of 177
CALCRL
Tclin
Family: GPCR
Novelty: 0.00568602
Score: 0.996
Data Source: Reactome,STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.991
Data Source: Reactome,STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.989
Data Source: STRINGDB
RAMP3
Tclin
Novelty: 0.01616194
Score: 0.988
Data Source: Reactome,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.987
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.987
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.983
Data Source: STRINGDB
ADM2
Tbio
Novelty: 0.00245573
Score: 0.983
Data Source: STRINGDB
CALCB
Tclin
Novelty: 0.02069808
Score: 0.974
Data Source: STRINGDB
CALCR
Tclin
Family: GPCR
Novelty: 0.00112487
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  2035.74

PubMed score by year
PubTator Score  998.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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