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Tbio
ADM
ADM

Protein Summary
Description
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278175
  • ENSP00000278175
  • ENSG00000148926
  • ENST00000525063
  • ENSP00000435124
  • ENST00000528655
  • ENSP00000436607

Symbol
  • AM
  • AM
  • PAMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
1
small molecule perturbation
1
PubMedID
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2073.66   (req: < 5)
Gene RIFs: 284   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2073.66   (req: >= 5)
Gene RIFs: 284   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.996
Data Source:  Reactome,STRINGDB
RAMP2
Tclin
Novelty:  0.01086538
Score:  0.991
Data Source:  Reactome,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.989
Data Source:  STRINGDB
RAMP3
Tclin
Novelty:  0.01616194
Score:  0.988
Data Source:  Reactome,STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.987
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.987
Data Source:  STRINGDB
IAPP
Tbio
Novelty:  0.0005195
Score:  0.983
Data Source:  STRINGDB
ADM2
Tbio
Novelty:  0.00245573
Score:  0.983
Data Source:  STRINGDB
CALCB
Tclin
Novelty:  0.02069808
Score:  0.974
Data Source:  STRINGDB
CALCR
Tclin
Family:  GPCR
Novelty:  0.00112487
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (75)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adrenomedullin measurement
1
3
3
96.7
hematocrit
2
3
3
91.7
hemoglobin measurement
2
3
3
90.4
appendicular lean mass
3
2
3
87.5
apolipoprotein A 1 measurement
1
2
2
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adrenomedullin measurement
3
96.7
hematocrit
3
91.7
hemoglobin measurement
3
90.4
appendicular lean mass
3
87.5
apolipoprotein A 1 measurement
2
81.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenomedullin
VGNC:3228
451021
Macaque
adrenomedullin
703305
Mouse
MGI:108058
11535
Rat
RGD:2047
25026
Dog
adrenomedullin
VGNC:37660
403817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenomedullin
Macaque
adrenomedullin
Mouse
Rat
Dog
adrenomedullin
Publication Statistics
PubMed Score 2073.66
PubMed score by year
PubTator Score 998.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title