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Tchem
SPR
Sepiapterin reductase

Protein Summary
Description
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234454
  • ENSP00000234454
  • ENSG00000116096

Symbol
  • SDR38C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
kinase perturbation
0.76
interacting protein
0.71
transcription factor binding site profile
0.71
cell type or tissue
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sepiapterin reductase
705317
Mouse
MGI:103078
20751
Rat
RGD:3753
29270
Dog
sepiapterin reductase
VGNC:49109
483118
Cow
sepiapterin reductase
533836
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sepiapterin reductase
Mouse
Rat
Dog
sepiapterin reductase
Cow
sepiapterin reductase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35270-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
Metabolism of vitamins and cofactors
Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of nitric oxide: eNOS activation and regulation
Metabolism of vitamins and cofactors
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Protein-Protein Interactions (85)
1 – 10 of 85
FGB
Tbio
Novelty: 0.00437751
p_int: 0.999789107
p_ni: 0.000210891
p_wrong: 2e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
PTS
Tbio
Family: Enzyme
Novelty: 0.00279396
Score: 0.989
Data Source: STRINGDB
QDPR
Tchem
Family: Enzyme
Novelty: 0.00836889
Score: 0.989
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.98
Data Source: STRINGDB
DHFR
Tclin
Family: Enzyme
Novelty: 0.00074557
Score: 0.977
Data Source: STRINGDB
CBR1
Tchem
Family: Enzyme
Novelty: 0.0062295
Score: 0.973
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.969
Data Source: STRINGDB
TPH1
Tclin
Family: Enzyme
Novelty: 0.00098637
Score: 0.965
Data Source: STRINGDB
AKR1B1
Tclin
Family: Enzyme
Novelty: 0.00045769
Score: 0.957
Data Source: STRINGDB
GCH1
Tbio
Family: Enzyme
Novelty: 0.0025793
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.12

PubMed score by year
PubTator Score  921.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer