Tchem SPR Sepiapterin reductase

Protein Summary

Description

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35270
• A8K741
• D6W5H2
• Q53GI9
• Q9UBB1
• SPR

Gene Name

• SPR

Ensembl ID

• ENST00000234454
• ENSP00000234454
• ENSG00000116096

Symbol

• SDR38C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
kinase perturbation	0.76
interacting protein	0.71
transcription factor binding site profile	0.71
cell type or tissue	0.65

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (8)

Explore Active Ligands

1 – 8 of 8

CHEMBL3900782

SPRTchem Enzyme

IC50 : 6

CHEMBL3915328

SPRTchem Enzyme

IC50 : 6.48

CHEMBL3943302

SPRTchem Enzyme

IC50 : 6.47

CHEMBL3977900

SPRTchem Enzyme

IC50 : 6.51

CHEMBL3976922

SPRTchem Enzyme

IC50 : 7.08

CHEMBL3893538

SPRTchem Enzyme

IC50 : 7.19

CHEMBL3986864

SPRTchem Enzyme

IC50 : 7.96

CHEMBL3948731

SPRTchem Enzyme

IC50 : 7.96000004

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	sepiapterin reductase		705317
Mouse	sepiapterin reductase	MGI:103078	20751
Rat	sepiapterin reductase	RGD:3753	29270
Dog	sepiapterin reductase	VGNC:49109	483118
Cow	sepiapterin reductase		533836

Species	Name	OMA	EggNOG	Inparanoid
Macaque	sepiapterin reductase
Mouse	sepiapterin reductase
Rat	sepiapterin reductase
Dog	sepiapterin reductase
Cow	sepiapterin reductase

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35270-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (11)

Reactome (6)

KEGG (2)

PathwayCommons (3)

Metabolism (R-HSA-1430728)

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Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of cofactors	19 targets	R-HSA-8978934
Reactome	Metabolism of nitric oxide: eNOS activation and regulation	15 targets	R-HSA-202131
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Reactome	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10 targets	R-HSA-1474151

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of cofactors	19 targets	R-HSA-8978934
Metabolism of nitric oxide: eNOS activation and regulation	15 targets	R-HSA-202131
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10 targets	R-HSA-1474151

Gene Ontology Terms (11)

Functions (3)

Components (3)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
sepiapterin reductase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
aldo-keto reductase (NADP) activity	Traceable Author Statement (TAS)	UniProtKB
NADP binding	Traceable Author Statement (TAS)	UniProtKB

Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

• See Interactions on String-DB

FGB

Tbio

Novelty: 0.00437751

p_int: 0.999789107

p_ni: 0.000210891

p_wrong: 2e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

PTS

Tbio

Family: Enzyme

Novelty: 0.00279396

Score: 0.989

Data Source: STRINGDB

QDPR

Tchem

Family: Enzyme

Novelty: 0.00836889

Score: 0.989

Data Source: STRINGDB

PAH

Tclin

Family: Enzyme

Novelty: 0.00337068

Score: 0.98

Data Source: STRINGDB

DHFR

Tclin

Family: Enzyme

Novelty: 0.00074557

Score: 0.977

Data Source: STRINGDB

CBR1

Tchem

Family: Enzyme

Novelty: 0.0062295

Score: 0.973

Data Source: STRINGDB

TH

Tclin

Family: Enzyme

Novelty: 0.00025719

Score: 0.969

Data Source: STRINGDB

TPH1

Tclin

Family: Enzyme

Novelty: 0.00098637

Score: 0.965

Data Source: STRINGDB

AKR1B1

Tclin

Family: Enzyme

Novelty: 0.00045769

Score: 0.957

Data Source: STRINGDB

GCH1

Tbio

Family: Enzyme

Novelty: 0.0025793

Score: 0.953

Data Source: STRINGDB

Publication Statistics

PubMed Score  39.12

PubMed score by year

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PubTator Score  921.8

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Dystonia
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype