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Tchem
SPR
Sepiapterin reductase

Protein Summary
Description
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234454
  • ENSP00000234454
  • ENSG00000116096

Symbol
  • SDR38C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
kinase perturbation
0.76
interacting protein
0.71
transcription factor binding site profile
0.71
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.63   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.63   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 963
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (85)
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999789107
p_ni:  0.000210891
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.989
Data Source:  STRINGDB
QDPR
Tchem
Family:  Enzyme
Novelty:  0.00836889
Score:  0.989
Data Source:  STRINGDB
PAH
Tclin
Family:  Enzyme
Novelty:  0.00337068
Score:  0.98
Data Source:  STRINGDB
DHFR
Tclin
Family:  Enzyme
Novelty:  0.00074557
Score:  0.977
Data Source:  STRINGDB
CBR1
Tchem
Family:  Enzyme
Novelty:  0.0062295
Score:  0.973
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.969
Data Source:  STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
Score:  0.965
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.957
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
Metabolism of vitamins and cofactors
Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of nitric oxide: eNOS activation and regulation
Metabolism of vitamins and cofactors
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sepiapterin reductase
705317
Mouse
MGI:103078
20751
Rat
RGD:3753
29270
Dog
sepiapterin reductase
VGNC:49109
483118
Cow
sepiapterin reductase
533836
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sepiapterin reductase
Mouse
Rat
Dog
sepiapterin reductase
Cow
sepiapterin reductase
Publication Statistics
PubMed Score 39.63
PubMed score by year
PubTator Score 921.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title