Protein Summary
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
- ENST00000234454
- ENSP00000234454
- ENSG00000116096
- SDR38C1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.76 | ||
kinase perturbation | 0.76 | ||
interacting protein | 0.71 | ||
transcription factor binding site profile | 0.71 | ||
cell type or tissue | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.63 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 314 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.63 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 314 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 963
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (963)
Protein-Protein Interactions (85)
FGB
Novelty: 0.00437751
p_int: 0.999789107
p_ni: 0.000210891
p_wrong: 2e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (6)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of cofactors | ||||
Reactome | Metabolism of nitric oxide: eNOS activation and regulation | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of cofactors | ||||
Metabolism of nitric oxide: eNOS activation and regulation | ||||
Metabolism of vitamins and cofactors | ||||
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 1 | 0 | 1.1 | 42.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | sepiapterin reductase | 705317 | ||||||
Mouse | MGI:103078 | 20751 | ||||||
Rat | RGD:3753 | 29270 | ||||||
Dog | sepiapterin reductase | VGNC:49109 | 483118 | |||||
Cow | sepiapterin reductase | 533836 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | sepiapterin reductase | |||||
Mouse | ||||||
Rat | ||||||
Dog | sepiapterin reductase | |||||
Cow | sepiapterin reductase | |||||
Publication Statistics
PubMed Score 39.63
PubMed score by year
PubTator Score 921.80
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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