You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GTF2F1
General transcription factor IIF subunit 1

Protein Summary
Description
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394456
  • ENSP00000377969
  • ENSG00000125651

Symbol
  • RAP74
  • BTF4
  • RAP74
  • TF2F1
  • TFIIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
disease perturbation
0.95
histone modification site profile
0.92
hub protein
0.85
kinase perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.05   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.05   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIF subunit 1
VGNC:2553
455639
Macaque
general transcription factor IIF subunit 1
699221
Mouse
MGI:1923848
98053
Rat
RGD:1359646
316123
Dog
general transcription factor IIF subunit 1
VGNC:41546
476731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIF subunit 1
Macaque
general transcription factor IIF subunit 1
Mouse
Rat
Dog
general transcription factor IIF subunit 1
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35269-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 57
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Diseases of signal transduction
ESR-mediated signaling
Estrogen-dependent gene expression
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (453)
1 – 10 of 453
PHF19
Tbio
Family: Epigenetic
Novelty: 0.02289037
p_int: 0.999929818
p_ni: 0.000070182
Score: 0.233
Data Source: BioPlex,STRINGDB
SPANXA1
Tbio
Novelty: 0.04707594
p_int: 0.99902598
p_ni: 0.00097402
Data Source: BioPlex
KCTD12
Tbio
Novelty: 0.0386637
p_int: 0.998508642
p_ni: 0.001491358
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.990762284
p_ni: 0.009237716
Data Source: BioPlex
PSME3
Tbio
Novelty: 0.01051254
p_int: 0.988672836
p_ni: 0.011327112
p_wrong: 5.2e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
C1QTNF2
Tbio
Novelty: 0.18607978
p_int: 0.987924617
p_ni: 0.012075377
p_wrong: 6e-9
Data Source: BioPlex
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.987681526
p_ni: 0.01231667
p_wrong: 0.000001804
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.986425179
p_ni: 0.013574765
p_wrong: 5.6e-8
Data Source: BioPlex
LSM7
Tbio
Novelty: 0.09112723
p_int: 0.974922947
p_ni: 0.025072844
p_wrong: 0.000004209
Score: 0.928
Data Source: BioPlex,STRINGDB
PCBD1
Tbio
Family: Enzyme
Novelty: 0.01564376
p_int: 0.974670476
p_ni: 0.025323953
p_wrong: 0.00000557
Data Source: BioPlex
Publication Statistics
PubMed Score  46.05

PubMed score by year
PubTator Score  52.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer