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Tbio
RPL22
60S ribosomal protein L22

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234875
  • ENSP00000346088
  • ENSG00000116251

Symbol
  • EAP
  • L22
  • HBP15
  • HBP15/L22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
virus perturbation
0.99
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.67   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.67   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
6
4
3
1.7
92.5
TPE interval measurement
1
1
3
78.5
electrocardiography
1
1
46
78.1
T wave morphology measurement
2
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
3
1.7
92.5
TPE interval measurement
3
78.5
electrocardiography
46
78.1
T wave morphology measurement
2
49.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L22
VGNC:1501
100612505
Macaque
ribosomal protein L22
703050
Mouse
MGI:99262
19934
Rat
RGD:621189
81768
Horse
ribosomal protein L22
VGNC:22525
100052308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L22
Macaque
ribosomal protein L22
Mouse
Rat
Horse
ribosomal protein L22
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35268-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (409)
1 – 10 of 409
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.999
Data Source:  STRINGDB
RPS28
Tbio
Novelty:  0.03303065
Score:  0.999
Data Source:  STRINGDB
RPS9
Tbio
Novelty:  0.01329701
Score:  0.999
Data Source:  STRINGDB
RPS25
Tbio
Novelty:  0.02812798
Score:  0.999
Data Source:  STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
Score:  0.999
Data Source:  STRINGDB
RPL10
Tbio
Novelty:  0.01299391
Score:  0.999
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.999
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.999
Data Source:  STRINGDB
RPS16
Tbio
Novelty:  0.00261983
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  221.67

PubMed score by year
PubTator Score  94.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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