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Tbio
RFC1
Replication factor C subunit 1

Protein Summary
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a ro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349703
  • ENSP00000261424
  • ENSG00000035928
  • ENST00000381897
  • ENSP00000371321

Symbol
  • RFC140
  • A1
  • RFC
  • PO-GA
  • RECC1
  • MHCBFB
  • RFC140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
1
molecular function
0.99
protein complex
0.99
protein domain
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.29   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.29   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (226)
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.999999502
p_ni:  4.98e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.999981551
p_ni:  0.000018448
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.935649951
p_ni:  0.064350048
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TEAD2
Tbio
Family:  TF
Novelty:  0.02487024
p_int:  0.911752666
p_ni:  0.088247334
Score:  0.187
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.841330144
p_ni:  0.158669855
p_wrong:  1e-9
Data Source:  BioPlex
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.811139701
p_ni:  0.188860299
Data Source:  BioPlex
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.805611876
p_ni:  0.194388124
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.753717885
p_ni:  0.246281756
p_wrong:  3.59e-7
Data Source:  BioPlex
RFC3
Tbio
Novelty:  0.02712951
Score:  0.999
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Damage Bypass
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Damage Bypass
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
13
10
18
8.1
98.8
alcohol use disorder measurement
5
5
2
7.9
97
mean corpuscular volume
3
3
3
93
mean corpuscular hemoglobin concentration
2
2
2
90.9
bitter alcoholic beverage consumption measurement
1
1
1
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
18
8.1
98.8
alcohol use disorder measurement
2
7.9
97
mean corpuscular volume
3
93
mean corpuscular hemoglobin concentration
2
90.9
bitter alcoholic beverage consumption measurement
1
80.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 1
VGNC:2002
461174
Macaque
replication factor C subunit 1
698987
Mouse
MGI:97891
19687
Rat
RGD:620619
89809
Dog
replication factor C subunit 1
VGNC:45492
479112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 1
Macaque
replication factor C subunit 1
Mouse
Rat
Dog
replication factor C subunit 1
Publication Statistics
PubMed Score 42.29
PubMed score by year
PubTator Score 148.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title