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Tbio
RFC4
Replication factor C subunit 4

Protein Summary
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template. The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296273
  • ENSP00000296273
  • ENSG00000163918
  • ENST00000392481
  • ENSP00000376272

Symbol
  • A1
  • RFC37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
protein complex
1
kinase perturbation
0.97
molecular function
0.97


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 4
VGNC:2535
100609026
Macaque
replication factor C subunit 4
100426721
Mouse
MGI:2146571
106344
Rat
RGD:1310142
288003
Dog
replication factor C subunit 4
VGNC:45495
478667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication factor C subunit 4
Macaque
replication factor C subunit 4
Mouse
Rat
Dog
replication factor C subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35249-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (61)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (457)
1 – 10 of 457
DSCC1
Tbio
Novelty: 0.04747149
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
RAD17
Tbio
Novelty: 0.00640979
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
RFC5
Tbio
Novelty: 0.03987481
p_int: 0.999999997
p_ni: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ATAD5
Tbio
Family: Enzyme
Novelty: 0.02459839
p_int: 0.999999981
p_ni: 5e-9
p_wrong: 1.4e-8
Score: 0.991
Data Source: BioPlex,STRINGDB
CHTF18
Tbio
Novelty: 0.02470494
p_int: 0.999999975
p_ni: 2.5e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
RFC1
Tbio
Novelty: 0.02642014
p_int: 0.999999502
p_ni: 4.98e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CHTF8
Tbio
Novelty: 0.15007488
p_int: 0.999996538
p_ni: 1.42e-7
p_wrong: 0.00000332
Score: 0.993
Data Source: BioPlex,STRINGDB
RFC2
Tbio
Novelty: 0.02088405
p_int: 0.999994269
p_ni: 0.000005731
Score: 0.999
Data Source: BioPlex,STRINGDB
RFC3
Tbio
Novelty: 0.02712951
p_int: 0.999706238
p_ni: 0.000293762
Score: 0.999
Data Source: BioPlex,STRINGDB
RAD1
Tchem
Novelty: 0.0060275
p_int: 0.999601989
p_ni: 0.000069714
p_wrong: 0.000328297
Score: 0.967
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.75

PubMed score by year
PubTator Score  14.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer