SFTPD
Pulmonary surfactant-associated protein D
Protein Summary
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
- ENST00000372292
- ENSP00000361366
- ENSG00000133661
- COLEC7
- PSPD
- SFTP4
- SP-D
- PSP-D
- SFTP4
- COLEC7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.95 | ||
protein domain | 0.85 | ||
biological process | 0.82 | ||
PubMedID | 0.74 | ||
disease | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1115.14 (req: < 5)
Gene RIFs: 225 (req: <= 3)
Antibodies: 456 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1115.14 (req: >= 5)
Gene RIFs: 225 (req: > 3)
Antibodies: 456 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0