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Tbio
SFTPD
Pulmonary surfactant-associated protein D

Protein Classes
Protein Summary
Description
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372292
  • ENSP00000361366
  • ENSG00000133661

Symbol
  • COLEC7
  • PSPD
  • SFTP4
  • SP-D
  • PSP-D
  • SFTP4
  • COLEC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
protein domain
0.85
biological process
0.82
PubMedID
0.74
disease
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 936.76   (req: < 5)
Gene RIFs: 184   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 936.76   (req: >= 5)
Gene RIFs: 184   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
52.8
2
1
0
1.1
36.2
1
1
0
1.2
33.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
52.8
0
1.1
36.2
0
1.2
33.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
surfactant protein D
678657
Mouse
MGI:109515
20390
Rat
RGD:3667
25350
Dog
surfactant protein D
VGNC:46086
489066
Horse
surfactant protein D
VGNC:22906
100066341
Species
Name
OMA
EggNOG
Inparanoid
Macaque
surfactant protein D
Mouse
Rat
Dog
surfactant protein D
Horse
surfactant protein D
Protein Structure (27 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35247-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (137)
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) (R-HSA-5688890)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Reactome
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Reactome
Disease
Reactome
Diseases associated with surfactant metabolism
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Disease
Diseases associated with surfactant metabolism
Diseases of metabolism
Protein-Protein Interactions (53)
1 – 10 of 53
SFTPB
Tbio
Novelty: 0.00163925
Score: 0.988
Data Source: STRINGDB
DMBT1
Tbio
Novelty: 0.00357297
Score: 0.988
Data Source: Reactome,STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
Score: 0.985
Data Source: STRINGDB
SFTPA1
Tbio
Novelty: 0.00530837
Score: 0.956
Data Source: STRINGDB
SFTPA2
Tbio
Novelty: 0.00283745
Score: 0.942
Data Source: STRINGDB
CSF2RB
Tclin
Novelty: 0.02093804
Score: 0.923
Data Source: STRINGDB
SFTA3
Tbio
Novelty: 0.00109932
Score: 0.922
Data Source: STRINGDB
CSF2RA
Tclin
Novelty: 0.00125121
Score: 0.921
Data Source: STRINGDB
MFAP4
Tbio
Novelty: 0.02023782
Score: 0.903
Data Source: STRINGDB
CKAP4
Tbio
Novelty: 0.02104039
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  936.76

PubMed score by year
PubTator Score  737.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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