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Tbio
RPA3
Replication protein A 14 kDa subunit

Protein Summary
Description
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223129
  • ENSP00000223129
  • ENSG00000106399
  • ENST00000396682
  • ENSP00000379914

Symbol
  • REPA3
  • RPA14
  • REPA3
  • RP-A p14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
virus perturbation
0.76
biological process
0.72
cellular component
0.67
pathway
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.31   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.31   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (294)
RPA2
Tbio
Novelty:  0.00879115
p_int:  0.999314025
p_ni:  0.000685975
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RPA4
Tbio
Novelty:  0.07275015
p_int:  0.976837784
p_ni:  0.023162216
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
Score:  0.999
Data Source:  Reactome,STRINGDB
WRN
Tbio
Family:  Enzyme
Novelty:  0.00163164
Score:  0.999
Data Source:  Reactome,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
Score:  0.999
Data Source:  STRINGDB
RAD52
Tchem
Novelty:  0.00125282
Score:  0.999
Data Source:  STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.999
Data Source:  STRINGDB
RMI1
Tbio
Novelty:  0.01222442
Score:  0.999
Data Source:  Reactome,STRINGDB
BLM
Tchem
Novelty:  0.00662454
Score:  0.999
Data Source:  Reactome,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4
52.2
1
1
0
4
52.2
monocyte percentage of leukocytes
1
1
1
27.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
52.2
0
4
52.2
monocyte percentage of leukocytes
1
27.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication protein A3
VGNC:4498
472290
Macaque
replication protein A3
696248
Mouse
MGI:1915490
68240
Rat
RGD:1306810
296883
Dog
replication protein A3
VGNC:45704
481449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication protein A3
Macaque
replication protein A3
Mouse
Rat
Dog
replication protein A3
Publication Statistics
PubMed Score 112.31
PubMed score by year
PubTator Score 49.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title