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Tbio
RPA3
Replication protein A 14 kDa subunit

Protein Summary
Description
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223129
  • ENSP00000223129
  • ENSG00000106399
  • ENST00000396682
  • ENSP00000379914

Symbol
  • REPA3
  • RPA14
  • REPA3
  • RP-A p14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
virus perturbation
0.76
biological process
0.72
cellular component
0.67
pathway
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (79)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (27)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (294)
1 – 10 of 294
RPA2
Tbio
Novelty: 0.00879115
p_int: 0.999314025
p_ni: 0.000685975
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RPA4
Tbio
Novelty: 0.07275015
p_int: 0.976837784
p_ni: 0.023162216
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.999
Data Source: Reactome,STRINGDB
WRN
Tbio
Family: Enzyme
Novelty: 0.00163164
Score: 0.999
Data Source: Reactome,STRINGDB
TIMELESS
Tbio
Novelty: 0.0041528
Score: 0.999
Data Source: STRINGDB
RAD52
Tbio
Novelty: 0.00125282
Score: 0.999
Data Source: STRINGDB
MCM2
Tbio
Novelty: 0.00276275
Score: 0.999
Data Source: STRINGDB
RMI1
Tbio
Novelty: 0.01222442
Score: 0.999
Data Source: Reactome,STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.999
Data Source: Reactome,STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  98.39

PubMed score by year
PubTator Score  49.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer