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Tbio
RDX
Radixin

Protein Summary
Description
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343115
  • ENSP00000342830
  • ENSG00000137710
  • ENST00000405097
  • ENSP00000384136
  • ENST00000528498
  • ENSP00000432112
  • ENST00000528900
  • ENSP00000433580
  • ENST00000530301
  • ENSP00000436277
  • ENST00000530749
  • ENSP00000437301
  • ENST00000544551
  • ENSP00000445826
  • ENST00000645495
  • ENSP00000496503
  • ENST00000647231
  • ENSP00000496414

Symbol
  • DFNB24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.98
kinase
0.91
interacting protein
0.9
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.23   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.23   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
EZR
Tbio
Novelty:  0.00115353
p_int:  0.999995925
p_ni:  0.000004075
Score:  0.938
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.917561397
p_ni:  0.082438603
Score:  0.929
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.916106026
p_ni:  0.083893974
Score:  0.186
Data Source:  BioPlex,STRINGDB
MISP
Tbio
Novelty:  0.02030151
p_int:  0.85536046
p_ni:  0.14463954
Score:  0.345
Data Source:  BioPlex,STRINGDB
SLC9A3R1
Tbio
Family:  Transporter
Novelty:  0.00357766
Score:  0.974
Data Source:  STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.973
Data Source:  STRINGDB
ROCK2
Tclin
Family:  Kinase
Novelty:  0.00242311
Score:  0.968
Data Source:  STRINGDB
L1CAM
Tbio
Novelty:  0.00307041
Score:  0.954
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.918
Data Source:  STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
Score:  0.903
Data Source:  STRINGDB
Pathways (25)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
4
5
78.6
2
1
1
1.1
71.5
apolipoprotein A 1 measurement
1
1
1
68.6
1
1
0
1.1
40.7
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
78.6
1
1.1
71.5
apolipoprotein A 1 measurement
1
68.6
0
1.1
40.7
0
1.1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radixin
VGNC:1029
466776
Macaque
radixin
709018
Mouse
MGI:97887
19684
Rat
RGD:1359472
315655
Dog
radixin
VGNC:45455
479446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radixin
Macaque
radixin
Mouse
Rat
Dog
radixin
Publication Statistics
PubMed Score 283.23
PubMed score by year
PubTator Score 683.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title