Protein Summary
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000343115
- ENSP00000342830
- ENSG00000137710
- ENST00000405097
- ENSP00000384136
- ENST00000528498
- ENSP00000432112
- ENST00000528900
- ENSP00000433580
- ENST00000530301
- ENSP00000436277
- ENST00000530749
- ENSP00000437301
- ENST00000544551
- ENSP00000445826
- ENST00000645495
- ENSP00000496503
- ENST00000647231
- ENSP00000496414
- DFNB24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.98 | ||
kinase | 0.91 | ||
interacting protein | 0.9 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 283.23 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 283.23 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (166)
EZR
Novelty: 0.00115353
p_int: 0.999995925
p_ni: 0.000004075
Score: 0.938
Data Source: BioPlex,STRINGDB
SLC9A3R2
Family: Transporter
Novelty: 0.01401705
p_int: 0.917561397
p_ni: 0.082438603
Score: 0.929
Data Source: BioPlex,STRINGDB
MRPL12
Novelty: 0.10646542
p_int: 0.916106026
p_ni: 0.083893974
Score: 0.186
Data Source: BioPlex,STRINGDB
MISP
Novelty: 0.02030151
p_int: 0.85536046
p_ni: 0.14463954
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (25)
Reactome (4)
KEGG (4)
PathwayCommons (2)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | Recycling pathway of L1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Recycling pathway of L1 | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (7)
Components (18)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 5 | 4 | 5 | 78.6 | |||||
2 | 1 | 1 | 1.1 | 71.5 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 68.6 | |||||
1 | 1 | 0 | 1.1 | 40.7 | |||||
1 | 1 | 0 | 1.1 | 40.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 5 | 78.6 | |||||
1 | 1.1 | 71.5 | |||||
apolipoprotein A 1 measurement | 1 | 68.6 | |||||
0 | 1.1 | 40.7 | |||||
0 | 1.1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | radixin | VGNC:1029 | 466776 | |||||
Macaque | radixin | 709018 | ||||||
Mouse | MGI:97887 | 19684 | ||||||
Rat | RGD:1359472 | 315655 | ||||||
Dog | radixin | VGNC:45455 | 479446 | |||||
Publication Statistics
PubMed Score 283.23
PubMed score by year
PubTator Score 683.19
PubTator score by year
Related Publications
Text Mined References (101)
GeneRif Annotations (60)
Items per page:
0 of 0
PMID | Year | Title |
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