Protein Classes
Protein Summary
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000343115
- ENSP00000342830
- ENSG00000137710
- ENST00000405097
- ENSP00000384136
- ENST00000528498
- ENSP00000432112
- ENST00000528900
- ENSP00000433580
- ENST00000530301
- ENSP00000436277
- ENST00000530749
- ENSP00000437301
- ENST00000544551
- ENSP00000445826
- ENST00000645495
- ENSP00000496503
- ENST00000647231
- ENSP00000496414
- DFNB24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.98 | ||
kinase | 0.91 | ||
interacting protein | 0.9 | ||
transcription factor perturbation | 0.88 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.41 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.41 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (25)
Reactome (4)
KEGG (4)
PathwayCommons (2)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | Recycling pathway of L1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Recycling pathway of L1 | ||||
Gene Ontology Terms (51)
Functions (7)
Components (18)
Processes (26)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (166)
1 – 10 of 166
EZR
Novelty: 0.00130199
p_int: 0.999995925
p_ni: 0.000004075
Score: 0.938
Data Source: BioPlex,STRINGDB
SLC9A3R2
Family: Transporter
Novelty: 0.01296563
p_int: 0.917561397
p_ni: 0.082438603
Score: 0.929
Data Source: BioPlex,STRINGDB
MRPL12
Novelty: 0.16043959
p_int: 0.916106026
p_ni: 0.083893974
Score: 0.186
Data Source: BioPlex,STRINGDB
MISP
Novelty: 0.01696113
p_int: 0.85536046
p_ni: 0.14463954
Score: 0.345
Data Source: BioPlex,STRINGDB
SLC9A3R1
Family: Transporter
Novelty: 0.0026167
Score: 0.974
Data Source: STRINGDB
ROCK1
Family: Kinase
Novelty: 0.00196146
Score: 0.973
Data Source: STRINGDB
ROCK2
Family: Kinase
Novelty: 0.00286446
Score: 0.968
Data Source: STRINGDB
L1CAM
Novelty: 0.00153954
Score: 0.954
Data Source: STRINGDB
CLTC
Novelty: 0.00348813
Score: 0.918
Data Source: STRINGDB
AP2A2
Novelty: 0.19247594
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score 233.41
PubMed score by year
PubTator Score 683.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDV
1-70
KKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKE
70-140
IHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKN
140-210
KKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRI
210-280
LALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMER
280-350
LKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE
350-420
LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHD
420-490
ENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRD
490-560
KYKTLRQIRQGNTKQRIDEFEAM
560-583
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
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