Protein Summary
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000343115
- ENSP00000342830
- ENSG00000137710
- ENST00000405097
- ENSP00000384136
- ENST00000528498
- ENSP00000432112
- ENST00000528900
- ENSP00000433580
- ENST00000530301
- ENSP00000436277
- ENST00000530749
- ENSP00000437301
- ENST00000544551
- ENSP00000445826
- ENST00000645495
- ENSP00000496503
- ENST00000647231
- ENSP00000496414
- DFNB24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.98 | ||
kinase | 0.91 | ||
interacting protein | 0.9 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 318.38 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 318.38 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0