Tbio NF2 Merlin

Protein Summary

Description

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35240
• O95683
• Q8WUJ2
• Q969N0
• Q969Q3
• Q96T30
• Q96T31
• Q96T32
• Q96T33
• Q9BTW3
• Q9UNG9
• Q9UNH3
• Q9UNH4

Gene Name

• NF2

Ensembl ID

• ENST00000334961
• ENSP00000335652
• ENSG00000186575
• ENST00000338641
• ENSP00000344666
• ENST00000353887
• ENSP00000340626
• ENST00000361166
• ENSP00000354529
• ENST00000361452
• ENSP00000354897
• ENST00000361676
• ENSP00000355183
• ENST00000397789
• ENSP00000380891
• ENST00000403435
• ENSP00000384029
• ENST00000403999
• ENSP00000384797
• ENST00000413209
• ENSP00000409921
• ENST00000432151
• ENSP00000395885

Symbol

• SCH
• ACN
• SCH
• BANF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.95
biological process	0.94
biological term	0.91
cellular component	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2317.6   (req: < 5)

Gene RIFs: 238   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2317.6   (req: >= 5)

Gene RIFs: 238   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0