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Tbio
NF2
Merlin

Protein Summary
Description
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334961
  • ENSP00000335652
  • ENSG00000186575
  • ENST00000338641
  • ENSP00000344666
  • ENST00000353887
  • ENSP00000340626
  • ENST00000361166
  • ENSP00000354529
  • ENST00000361452
  • ENSP00000354897
  • ENST00000361676
  • ENSP00000355183
  • ENST00000397789
  • ENSP00000380891
  • ENST00000403435
  • ENSP00000384029
  • ENST00000403999
  • ENSP00000384797
  • ENST00000413209
  • ENSP00000409921
  • ENST00000432151
  • ENSP00000395885

Symbol
  • SCH
  • ACN
  • SCH
  • BANF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.95
biological process
0.94
biological term
0.91
cellular component
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1953.27   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1953.27   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurofibromin 2
VGNC:12905
458744
Macaque
neurofibromin 2
714945
Mouse
MGI:97307
18016
Rat
RGD:3169
25744
Dog
neurofibromin 2
VGNC:43762
477535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurofibromin 2
Macaque
neurofibromin 2
Mouse
Rat
Dog
neurofibromin 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35240-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PAKs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases activate PAKs
Gene Ontology Terms (45)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (145)
1 – 10 of 145
PPFIA1
Tbio
Novelty: 0.01904029
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
TSPYL4
Tdark
Novelty: 0.4538252
p_int: 0.999576803
p_ni: 0.000422264
p_wrong: 9.32e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999555445
p_ni: 0.000444555
Score: 0.343
Data Source: BioPlex,STRINGDB
AMOTL1
Tbio
Novelty: 0.03842225
p_int: 0.999059884
p_ni: 0.000940116
Score: 0.918
Data Source: BioPlex,STRINGDB
CCNL2
Tbio
Novelty: 0.03667817
p_int: 0.995547343
p_ni: 0.004397645
p_wrong: 0.000055012
Score: 0.181
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.00317454
p_int: 0.980176947
p_ni: 0.019823053
Score: 0.212
Data Source: BioPlex,STRINGDB
LATS2
Tchem
Family: Kinase
Novelty: 0.00521035
Score: 0.992
Data Source: STRINGDB
LATS1
Tbio
Family: Kinase
Novelty: 0.00369058
Score: 0.971
Data Source: STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
Score: 0.966
Data Source: Reactome,STRINGDB
WWC1
Tbio
Novelty: 0.00905646
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  1953.27

PubMed score by year
PubTator Score  1656.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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