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Tbio
SERPINB6
Serpin B6

Protein Summary
Description
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335686
  • ENSP00000338358
  • ENSG00000124570
  • ENST00000380520
  • ENSP00000369891
  • ENST00000380524
  • ENSP00000369896
  • ENST00000380529
  • ENSP00000369901
  • ENST00000380539
  • ENSP00000369912
  • ENST00000380546
  • ENSP00000369919
  • ENST00000643098
  • ENSP00000493936
  • ENST00000644178
  • ENSP00000496073
  • ENST00000644388
  • ENSP00000494650

Symbol
  • PI6
  • PTI
  • CAP
  • PI6
  • PTI
  • PI-6
  • SPI3
  • DFNB91
  • MSTP057
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.93
kinase perturbation
0.93
gene perturbation
0.78
tissue
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (111)
1 – 10 of 111
SERPINB8
Tbio
Novelty:  0.03308357
p_int:  0.999999888
p_ni:  1.6e-8
p_wrong:  9.6e-8
Score:  0.346
Data Source:  BioPlex,STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
p_int:  0.838717049
p_ni:  0.161279445
p_wrong:  0.000003507
Score:  0.436
Data Source:  BioPlex,STRINGDB
PLAU
Tchem
Family:  Enzyme
Novelty:  0.0005322
Score:  0.942
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.932
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.924
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.916
Data Source:  STRINGDB
LAMTOR3
Tbio
Novelty:  0.050644
Score:  0.915
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.912
Data Source:  STRINGDB
SLC11A1
Tbio
Family:  Transporter
Novelty:  0.00121416
Score:  0.911
Data Source:  STRINGDB
LAMTOR2
Tbio
Novelty:  0.05210182
Score:  0.911
Data Source:  STRINGDB
Pathways (7)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
27.3
1
1
0
1.3
21.5
monocyte count
1
1
1
12.8
platelet crit
1
1
1
8.8
reticulocyte count
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
27.3
0
1.3
21.5
monocyte count
1
12.8
platelet crit
1
8.8
reticulocyte count
1
6
Find similar targets by:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 6
VGNC:9956
100611419
Mouse
MGI:2145481
97848
Rat
RGD:1310452
364705
Horse
serpin family B member 6
VGNC:49518
100050295
Platypus
serpin B6-like
100074025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 6
Mouse
Rat
Horse
serpin family B member 6
Platypus
serpin B6-like
Publication Statistics
PubMed Score 177.52
PubMed score by year
PubTator Score 55.94
PubTator score by year