Protein Summary
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript vari ...more
- ENST00000335686
- ENSP00000338358
- ENSG00000124570
- ENST00000380520
- ENSP00000369891
- ENST00000380524
- ENSP00000369896
- ENST00000380529
- ENSP00000369901
- ENST00000380539
- ENSP00000369912
- ENST00000380546
- ENSP00000369919
- ENST00000643098
- ENSP00000493936
- ENST00000644178
- ENSP00000496073
- ENST00000644388
- ENSP00000494650
- PI6
- PTI
- CAP
- PI6
- PTI
- PI-6
- SPI3
- DFNB91
- MSTP057
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.93 | ||
gene perturbation | 0.78 | ||
tissue | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287.23 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287.23 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0