Tchem PTPN7 Tyrosine-protein phosphatase non-receptor type 7

Protein Summary

Description

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P35236
• B3KXE1
• Q53XK4
• Q5SXQ0
• Q5SXQ1
• Q9BV05

Gene Name

• PTPN7

Ensembl ID

• ENST00000309017
• ENSP00000309116
• ENSG00000143851
• ENST00000367279
• ENSP00000356248
• ENST00000495688
• ENSP00000420506

Symbol

• LPTP
• HEPTP
• PTPNI
• BPTP-4
• LC-PTP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.8
cell type or tissue	0.74
tissue sample	0.74
protein domain	0.73
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Tyrosine-protein Phosphatase Non-receptor Type 7

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Tyrosine-protein Phosphatase Non-receptor Type 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.34   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.34   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0