You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PHB
Prohibitin

Protein Summary
Description
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300408
  • ENSP00000300408
  • ENSG00000167085
  • ENST00000511832
  • ENSP00000425035
  • ENST00000614445
  • ENSP00000479488
  • ENST00000617874
  • ENSP00000484113

Symbol
  • PHB1
  • HEL-215
  • HEL-S-54e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
hub protein
0.99
transcription factor perturbation
0.97
biological process
0.91
histone modification site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.22   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 649   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.22   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 649   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Gene Ontology Terms (59)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
RIC3
Tbio
Novelty: 0.02945063
p_int: 0.999632845
p_ni: 0.000367155
Score: 0.221
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.03141831
p_int: 0.927805484
p_ni: 0.072194516
Data Source: BioPlex
HIKESHI
Tbio
Novelty: 0.08920986
p_int: 0.874658542
p_ni: 0.125336637
p_wrong: 0.000004821
Score: 0.301
Data Source: BioPlex,STRINGDB
PHB2
Tbio
Novelty: 0.00467021
Score: 0.999
Data Source: Reactome,STRINGDB
AFG3L2
Tbio
Family: Enzyme
Novelty: 0.02183644
Score: 0.981
Data Source: Reactome,STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00141214
Score: 0.967
Data Source: Reactome,STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00165174
Score: 0.965
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00018907
Score: 0.949
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.0080419
Score: 0.94
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008788
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  529.22

PubMed score by year
PubTator Score  326.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: