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Tbio
PHB
Prohibitin

Protein Summary
Description
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300408
  • ENSP00000300408
  • ENSG00000167085
  • ENST00000511832
  • ENSP00000425035
  • ENST00000614445
  • ENSP00000479488
  • ENST00000617874
  • ENSP00000484113

Symbol
  • PHB1
  • HEL-215
  • HEL-S-54e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
hub protein
0.99
transcription factor perturbation
0.97
biological process
0.91
histone modification site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.6   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 649   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.6   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 649   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
69.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
69.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prohibitin
VGNC:9514
455205
Macaque
prohibitin
699334
Mouse
MGI:97572
18673
Rat
RGD:3322
25344
Dog
prohibitin
480547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prohibitin
Macaque
prohibitin
Mouse
Rat
Dog
prohibitin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35232-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Gene Ontology Terms (59)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
RIC3
Tbio
Novelty: 0.0162412
p_int: 0.999632845
p_ni: 0.000367155
Score: 0.221
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.927805484
p_ni: 0.072194516
Data Source: BioPlex
HIKESHI
Tbio
Novelty: 0.0683189
p_int: 0.874658542
p_ni: 0.125336637
p_wrong: 0.000004821
Score: 0.301
Data Source: BioPlex,STRINGDB
PHB2
Tbio
Novelty: 0.00458856
Score: 0.999
Data Source: Reactome,STRINGDB
AFG3L2
Tbio
Family: Enzyme
Novelty: 0.01770465
Score: 0.981
Data Source: Reactome,STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
Score: 0.967
Data Source: Reactome,STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.965
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.949
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.94
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  592.60

PubMed score by year
PubTator Score  326.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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