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Tchem
NOS2
Nitric oxide synthase, inducible

Protein Summary
Description
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313735
  • ENSP00000327251
  • ENSG00000007171
  • ENST00000621962
  • ENSP00000482291

Symbol
  • NOS2A
  • NOS
  • INOS
  • NOS2A
  • HEP-NOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
protein domain
1
biological process
0.99
co-expressed gene
0.99
drug
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2927.14   (req: < 5)
Gene RIFs: 588   (req: <= 3)
Antibodies: 1007   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2927.14   (req: >= 5)
Gene RIFs: 588   (req: > 3)
Antibodies: 1007   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 406
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (406)
1 – 10 of 406
CHEMBL491923
chemical structure image
CHEMBL1762472
chemical structure image
CHEMBL312870
chemical structure image
CHEMBL256147,CHEMBL3217190
chemical structure image
CHEMBL113793
chemical structure image
CHEMBL269058
chemical structure image
CHEMBL447183
chemical structure image
CHEMBL545673,CHEMBL451666
chemical structure image
CHEMBL1256014,CHEMBL7890
chemical structure image
CHEMBL293022
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
89.1
psoriasis vulgaris
1
1
0
1.3
53.5
nitric oxide exhalation measurement
1
1
1
43.7
eosinophil count
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
89.1
psoriasis vulgaris
0
1.3
53.5
nitric oxide exhalation measurement
1
43.7
eosinophil count
1
43.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 2
VGNC:9479
455026
Mouse
MGI:97361
18126
Rat
Dog
nitric oxide synthase 2
VGNC:43895
403822
Horse
nitric oxide synthase 2
VGNC:20814
791246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 2
Mouse
Rat
Dog
nitric oxide synthase 2
Horse
nitric oxide synthase 2
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (50)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Hemostasis
Immune System
Innate Immune System
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (241)
1 – 10 of 241
CALM1
Tclin
Novelty: 0.00308267
Score: 0.992
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.984
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.981
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.978
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.974
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.972
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.965
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.958
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.956
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  2927.14

PubMed score by year
PubTator Score  6043.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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