Tchem NOS2 Nitric oxide synthase, inducible

Protein Summary

Description

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35228
• A1L3U5
• B7ZLY2
• O60757
• O94994
• Q16263
• Q16692
• Q4TTS5
• Q9UD42

Gene Name

• NOS2

Ensembl ID

• ENST00000313735
• ENSP00000327251
• ENSG00000007171
• ENST00000621962
• ENSP00000482291

Symbol

• NOS2A
• NOS
• INOS
• NOS2A
• HEP-NOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
protein domain	1
biological process	0.99
co-expressed gene	0.99
drug	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3106.71   (req: < 5)

Gene RIFs: 656   (req: <= 3)

Antibodies: 1007   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3106.71   (req: >= 5)

Gene RIFs: 656   (req: > 3)

Antibodies: 1007   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 418

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1