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Tbio
IL13
Interleukin-13

Protein Classes
Protein Summary
Description
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304506
  • ENSP00000304915
  • ENSG00000169194

Symbol
  • NC30
  • P600
  • IL-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.98
co-expressed gene
0.98
phenotype
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4421.14   (req: < 5)
Gene RIFs: 448   (req: <= 3)
Antibodies: 1040   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4421.14   (req: >= 5)
Gene RIFs: 448   (req: > 3)
Antibodies: 1040   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
97
Eczema
3
2
0
1.1
95
2
2
0
1.1
94.9
2
2
0
1.4
93.5
4
2
0
1.2
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97
Eczema
0
1.1
95
0
1.1
94.9
0
1.4
93.5
0
1.2
91.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 13
VGNC:4042
107974854
Macaque
interleukin 13
574325
Mouse
MGI:96541
16163
Rat
RGD:68949
116553
Dog
interleukin 13
VGNC:41936
442990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 13
Macaque
interleukin 13
Mouse
Rat
Dog
interleukin 13
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (412)
1 – 10 of 412
IL4R
Tclin
Novelty: 0.00359183
Score: 0.998
Data Source: Reactome,STRINGDB
IL13RA1
Tbio
Novelty: 0.03308775
Score: 0.996
Data Source: Reactome,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
Score: 0.996
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.992
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.99
Data Source: Reactome,STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.99
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.988
Data Source: STRINGDB
VCAM1
Tchem
Novelty: 0.00022504
Score: 0.987
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.983
Data Source: STRINGDB
CCL2
Tchem
Novelty: 0.00010958
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  4421.14

PubMed score by year
PubTator Score  2182.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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