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Tchem
CTNNB1
Catenin beta-1

Protein Summary
Description
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349496
  • ENSP00000344456
  • ENSG00000168036
  • ENST00000396183
  • ENSP00000379486
  • ENST00000396185
  • ENSP00000379488
  • ENST00000405570
  • ENSP00000385604
  • ENST00000431914
  • ENSP00000412219
  • ENST00000433400
  • ENSP00000387455
  • ENST00000441708
  • ENSP00000401599
  • ENST00000450969
  • ENSP00000409302
  • ENST00000642248
  • ENSP00000495244
  • ENST00000642315
  • ENSP00000495076
  • ENST00000642426
  • ENSP00000495719
  • ENST00000642992
  • ENSP00000496385
  • ENST00000643031
  • ENSP00000495450
  • ENST00000643297
  • ENSP00000494677
  • ENST00000643541
  • ENSP00000494411
  • ENST00000643977
  • ENSP00000494053
  • ENST00000643992
  • ENSP00000493610
  • ENST00000644867
  • ENSP00000495992
  • ENST00000645210
  • ENSP00000496180
  • ENST00000645320
  • ENSP00000495360
  • ENST00000645982
  • ENSP00000494845
  • ENST00000646369
  • ENSP00000494914
  • ENST00000646725
  • ENSP00000496021
  • ENST00000647390
  • ENSP00000493533

Symbol
  • CTNNB
  • EVR7
  • CTNNB
  • MRD19
  • armadillo
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11066.41   (req: < 5)
Gene RIFs: 1846   (req: <= 3)
Antibodies: 4448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11066.41   (req: >= 5)
Gene RIFs: 1846   (req: > 3)
Antibodies: 4448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 164
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (187)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 54
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Gene Ontology Terms (207)
Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (996)
1 – 10 of 996
CDH8
Tbio
Novelty: 0.05007376
p_int: 0.999989855
p_ni: 0.000010145
Score: 0.972
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00096405
p_int: 0.999923201
p_ni: 0.000076799
Score: 0.988
Data Source: BioPlex,STRINGDB
CTNNA3
Tbio
Novelty: 0.02196369
p_int: 0.999152062
p_ni: 0.000847938
Score: 0.975
Data Source: BioPlex,STRINGDB
CTNNBIP1
Tbio
Novelty: 0.08527893
p_int: 0.978842569
p_ni: 0.021157431
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01762102
p_int: 0.973890675
p_ni: 0.026109325
Score: 0.717
Data Source: BioPlex,STRINGDB
SAPCD1
Tdark
Novelty: 1.81818182
p_int: 0.836955285
p_ni: 0.163044715
Score: 0.381
Data Source: BioPlex,STRINGDB
CTNND1
Tbio
Novelty: 0.00399968
p_int: 0.804618377
p_ni: 0.195381623
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
SLAMF7
Tclin
Novelty: 0.01669532
p_int: 0.790673738
p_ni: 0.209326262
Score: 0.187
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00393331
Score: 0.999
Data Source: Reactome,STRINGDB
FER
Tclin
Family: Kinase
Novelty: 0.00837221
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  11066.41

PubMed score by year
PubTator Score  8422.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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