CTNNB1
Catenin beta-1
Protein Summary
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMe ...more
- ENST00000349496
- ENSP00000344456
- ENSG00000168036
- ENST00000396183
- ENSP00000379486
- ENST00000396185
- ENSP00000379488
- ENST00000405570
- ENSP00000385604
- ENST00000431914
- ENSP00000412219
- ENST00000433400
- ENSP00000387455
- ENST00000441708
- ENSP00000401599
- ENST00000450969
- ENSP00000409302
- ENST00000642248
- ENSP00000495244
- ENST00000642315
- ENSP00000495076
- ENST00000642426
- ENSP00000495719
- ENST00000642992
- ENSP00000496385
- ENST00000643031
- ENSP00000495450
- ENST00000643297
- ENSP00000494677
- ENST00000643541
- ENSP00000494411
- ENST00000643977
- ENSP00000494053
- ENST00000643992
- ENSP00000493610
- ENST00000644867
- ENSP00000495992
- ENST00000645210
- ENSP00000496180
- ENST00000645320
- ENSP00000495360
- ENST00000645982
- ENSP00000494845
- ENST00000646369
- ENSP00000494914
- ENST00000646725
- ENSP00000496021
- ENST00000647390
- ENSP00000493533
- CTNNB
- EVR7
- CTNNB
- MRD19
- armadillo
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16625.96 (req: < 5)
Gene RIFs: 2469 (req: <= 3)
Antibodies: 4448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16625.96 (req: >= 5)
Gene RIFs: 2469 (req: > 3)
Antibodies: 4448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 164
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0