Protein Summary
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMe ...more
- ENST00000349496
- ENSP00000344456
- ENSG00000168036
- ENST00000396183
- ENSP00000379486
- ENST00000396185
- ENSP00000379488
- ENST00000405570
- ENSP00000385604
- ENST00000431914
- ENSP00000412219
- ENST00000433400
- ENSP00000387455
- ENST00000441708
- ENSP00000401599
- ENST00000450969
- ENSP00000409302
- ENST00000642248
- ENSP00000495244
- ENST00000642315
- ENSP00000495076
- ENST00000642426
- ENSP00000495719
- ENST00000642992
- ENSP00000496385
- ENST00000643031
- ENSP00000495450
- ENST00000643297
- ENSP00000494677
- ENST00000643541
- ENSP00000494411
- ENST00000643977
- ENSP00000494053
- ENST00000643992
- ENSP00000493610
- ENST00000644867
- ENSP00000495992
- ENST00000645210
- ENSP00000496180
- ENST00000645320
- ENSP00000495360
- ENST00000645982
- ENSP00000494845
- ENST00000646369
- ENSP00000494914
- ENST00000646725
- ENSP00000496021
- ENST00000647390
- ENSP00000493533
- CTNNB
- EVR7
- CTNNB
- MRD19
- armadillo
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14469.01 (req: < 5)
Gene RIFs: 1846 (req: <= 3)
Antibodies: 4448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14469.01 (req: >= 5)
Gene RIFs: 1846 (req: > 3)
Antibodies: 4448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 164
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 1 | 1 | 80.3 | |||||
cognitive function measurement | 1 | 1 | 1 | 72.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 1 | 80.3 | |||||
cognitive function measurement | 1 | 72.4 | |||||
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | catenin beta 1 | VGNC:6197 | 450183 | |||||
Macaque | catenin beta 1 | 574265 | ||||||
Mouse | MGI:88276 | 12387 | ||||||
Rat | RGD:70487 | 84353 | ||||||
Dog | catenin beta 1 | VGNC:39700 | 477032 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | catenin beta 1 | |||||
Macaque | catenin beta 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | catenin beta 1 | |||||
Protein Structure (18 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 18
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (187)
Reactome (54)
KEGG (28)
PathwayCommons (59)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 54
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adherens junctions interactions | ||||
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Gene Ontology Terms (207)
Functions (22)
Components (43)
Processes (142)
Items per page:
10
1 – 10 of 22
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (996)
1 – 10 of 996
CDH8
Novelty: 0.04055999
p_int: 0.999989855
p_ni: 0.000010145
Score: 0.972
Data Source: BioPlex,STRINGDB
CDH5
Novelty: 0.00072649
p_int: 0.999923201
p_ni: 0.000076799
Score: 0.988
Data Source: BioPlex,STRINGDB
CTNNA3
Novelty: 0.01472452
p_int: 0.999152062
p_ni: 0.000847938
Score: 0.975
Data Source: BioPlex,STRINGDB
CTNNBIP1
Novelty: 0.05434645
p_int: 0.978842569
p_ni: 0.021157431
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Novelty: 0.01605171
p_int: 0.973890675
p_ni: 0.026109325
Score: 0.717
Data Source: BioPlex,STRINGDB
SAPCD1
Novelty: 0.90892824
p_int: 0.836955285
p_ni: 0.163044715
Score: 0.381
Data Source: BioPlex,STRINGDB
CTNND1
Novelty: 0.00335459
p_int: 0.804618377
p_ni: 0.195381623
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
SLAMF7
Novelty: 0.01014396
p_int: 0.790673738
p_ni: 0.209326262
Score: 0.187
Data Source: BioPlex,STRINGDB
BTRC
Novelty: 0.00293475
Score: 0.999
Data Source: Reactome,STRINGDB
FER
Family: Kinase
Novelty: 0.01531184
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 14469.01
PubMed score by year
PubTator Score 8422.76
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword