Protein Summary
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMe ...more
- ENST00000349496
- ENSP00000344456
- ENSG00000168036
- ENST00000396183
- ENSP00000379486
- ENST00000396185
- ENSP00000379488
- ENST00000405570
- ENSP00000385604
- ENST00000431914
- ENSP00000412219
- ENST00000433400
- ENSP00000387455
- ENST00000441708
- ENSP00000401599
- ENST00000450969
- ENSP00000409302
- ENST00000642248
- ENSP00000495244
- ENST00000642315
- ENSP00000495076
- ENST00000642426
- ENSP00000495719
- ENST00000642992
- ENSP00000496385
- ENST00000643031
- ENSP00000495450
- ENST00000643297
- ENSP00000494677
- ENST00000643541
- ENSP00000494411
- ENST00000643977
- ENSP00000494053
- ENST00000643992
- ENSP00000493610
- ENST00000644867
- ENSP00000495992
- ENST00000645210
- ENSP00000496180
- ENST00000645320
- ENSP00000495360
- ENST00000645982
- ENSP00000494845
- ENST00000646369
- ENSP00000494914
- ENST00000646725
- ENSP00000496021
- ENST00000647390
- ENSP00000493533
- CTNNB
- EVR7
- CTNNB
- MRD19
- armadillo
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11066.41 (req: < 5)
Gene RIFs: 1846 (req: <= 3)
Antibodies: 4448 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11066.41 (req: >= 5)
Gene RIFs: 1846 (req: > 3)
Antibodies: 4448 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 164
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (187)
Reactome (54)
KEGG (28)
PathwayCommons (59)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 54
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adherens junctions interactions | ||||
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Gene Ontology Terms (207)
Functions (22)
Components (43)
Processes (142)
Items per page:
10
1 – 10 of 22
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (996)
1 – 10 of 996
CDH8
Novelty: 0.05007376
p_int: 0.999989855
p_ni: 0.000010145
Score: 0.972
Data Source: BioPlex,STRINGDB
CDH5
Novelty: 0.00096405
p_int: 0.999923201
p_ni: 0.000076799
Score: 0.988
Data Source: BioPlex,STRINGDB
CTNNA3
Novelty: 0.02196369
p_int: 0.999152062
p_ni: 0.000847938
Score: 0.975
Data Source: BioPlex,STRINGDB
CTNNBIP1
Novelty: 0.08527893
p_int: 0.978842569
p_ni: 0.021157431
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Novelty: 0.01762102
p_int: 0.973890675
p_ni: 0.026109325
Score: 0.717
Data Source: BioPlex,STRINGDB
SAPCD1
Novelty: 1.81818182
p_int: 0.836955285
p_ni: 0.163044715
Score: 0.381
Data Source: BioPlex,STRINGDB
CTNND1
Novelty: 0.00399968
p_int: 0.804618377
p_ni: 0.195381623
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
SLAMF7
Novelty: 0.01669532
p_int: 0.790673738
p_ni: 0.209326262
Score: 0.187
Data Source: BioPlex,STRINGDB
BTRC
Novelty: 0.00393331
Score: 0.999
Data Source: Reactome,STRINGDB
FER
Family: Kinase
Novelty: 0.00837221
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 11066.41
PubMed score by year
PubTator Score 8422.76
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait