Tchem CTNNB1 Catenin beta-1

Protein Summary

Description

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• P35222
• A8K1L7
• Q8NEW9
• Q8NI94
• Q9H391

Gene Name

• CTNNB1

Ensembl ID

• ENST00000349496
• ENSP00000344456
• ENSG00000168036
• ENST00000396183
• ENSP00000379486
• ENST00000396185
• ENSP00000379488
• ENST00000405570
• ENSP00000385604
• ENST00000431914
• ENSP00000412219
• ENST00000433400
• ENSP00000387455
• ENST00000441708
• ENSP00000401599
• ENST00000450969
• ENSP00000409302
• ENST00000642248
• ENSP00000495244
• ENST00000642315
• ENSP00000495076
• ENST00000642426
• ENSP00000495719
• ENST00000642992
• ENSP00000496385
• ENST00000643031
• ENSP00000495450
• ENST00000643297
• ENSP00000494677
• ENST00000643541
• ENSP00000494411
• ENST00000643977
• ENSP00000494053
• ENST00000643992
• ENSP00000493610
• ENST00000644867
• ENSP00000495992
• ENST00000645210
• ENSP00000496180
• ENST00000645320
• ENSP00000495360
• ENST00000645982
• ENSP00000494845
• ENST00000646369
• ENSP00000494914
• ENST00000646725
• ENSP00000496021
• ENST00000647390
• ENSP00000493533

Symbol

• CTNNB
• EVR7
• CTNNB
• MRD19
• armadillo

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
hub protein	1
interacting protein	1

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15144.63   (req: < 5)

Gene RIFs: 1846   (req: <= 3)

Antibodies: 4448   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15144.63   (req: >= 5)

Gene RIFs: 1846   (req: > 3)

Antibodies: 4448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 164

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (10)

Explore Active Ligands

1 – 10 of 10

CHEMBL2397076

CTNNB1Tchem

Kd : 7.89

CHEMBL2397077

CTNNB1Tchem

Kd : 7.28

CHEMBL2397073

CTNNB1Tchem

Kd : 7.22

CHEMBL4074243

CTNNB1Tchem

Ki : 6.03

CHEMBL4548532

CTNNB1Tchem

Ki : 6.36

N'-((5-methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide

CTNNB1Tchem

Kd : 6.35

SID14728191

CTNNB1Tchem

IC50 : 6.25

CHEMBL4451478

CTNNB1Tchem

Ki : 6.19

SID22405070

CTNNB1Tchem

IC50 : 6.11

CHEMBL3589156

CTNNB1Tchem

Ki : 6

GWAS Traits (11)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bone density	EFO_0003923	3	3	3		86.4
balding measurement	EFO_0007825	1	1	1		66
mathematical ability	EFO_0004875	3	2	3		55.1
cognitive function measurement	EFO_0008354	1	1	1		44.2
heel bone mineral density	EFO_0009270	1	1	1		32.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bone density	EFO_0003923	3		86.4
balding measurement	EFO_0007825	1		66
mathematical ability	EFO_0004875	3		55.1
cognitive function measurement	EFO_0008354	1		44.2
heel bone mineral density	EFO_0009270	1		32.7

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	catenin beta 1	VGNC:6197	450183
Macaque	catenin beta 1		574265
Mouse	catenin (cadherin associated protein), beta 1	MGI:88276	12387
Rat	catenin beta 1	RGD:70487	84353
Dog	catenin beta 1	VGNC:39700	477032

Species	Name	OMA	EggNOG	Inparanoid
Chimp	catenin beta 1
Macaque	catenin beta 1
Mouse	catenin (cadherin associated protein), beta 1
Rat	catenin beta 1
Dog	catenin beta 1

Protein Structure (18 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-P35222-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (187)

Reactome (54)

KEGG (28)

PathwayCommons (59)

WikiPathways (46)

Adherens junctions interactions (R-HSA-418990)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153

Gene Ontology Terms (207)

Functions (22)

Components (43)

Processes (142)

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Items per page:

10

1 – 10 of 22

GO Term	Evidence	Assigned by
RNA polymerase II transcription factor binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
alpha-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from Physical Interaction (IPI)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
estrogen receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
I-SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
kinase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
nuclear hormone receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (996)

Explore Interacting Targets

1 – 10 of 996

• See Interactions on String-DB

CDH8

Tbio

Novelty:  0.04055999

p_int:  0.999989855

p_ni:  0.000010145

Score:  0.972

Data Source:  BioPlex,STRINGDB

CDH5

Tbio

Novelty:  0.00072649

p_int:  0.999923201

p_ni:  0.000076799

Score:  0.988

Data Source:  BioPlex,STRINGDB

CTNNA3

Tbio

Novelty:  0.01472452

p_int:  0.999152062

p_ni:  0.000847938

Score:  0.975

Data Source:  BioPlex,STRINGDB

CTNNBIP1

Tbio

Novelty:  0.05434645

p_int:  0.978842569

p_ni:  0.021157431

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

TAX1BP3

Tbio

Novelty:  0.01605171

p_int:  0.973890675

p_ni:  0.026109325

Score:  0.717

Data Source:  BioPlex,STRINGDB

SAPCD1

Tdark

Novelty:  0.90892824

p_int:  0.836955285

p_ni:  0.163044715

Score:  0.381

Data Source:  BioPlex,STRINGDB

CTNND1

Tbio

Novelty:  0.00335459

p_int:  0.804618377

p_ni:  0.195381623

Score:  0.988

Data Source:  BioPlex,Reactome,STRINGDB

SLAMF7

Tclin

Novelty:  0.01014396

p_int:  0.790673738

p_ni:  0.209326262

Score:  0.187

Data Source:  BioPlex,STRINGDB

BTRC

Tbio

Novelty:  0.00293475

Score:  0.999

Data Source:  Reactome,STRINGDB

FER

Tclin

Family:  Kinase

Novelty:  0.01531184

Score:  0.999

Data Source:  STRINGDB

Publication Statistics

PubMed Score  15144.63

PubMed score by year

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PubTator Score  8422.76

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Cell adhesion
Cell junction
Cell membrane
Cell projection
Chromosomal rearrangement
Complete proteome
Cytoplasm

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
body mass index
bone density
cognitive function measurement
femoral neck bone mineral density
heel bone mineral density
mathematical ability
Myopia
refractive error measurement
spine bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype