You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CTNNA1
Catenin alpha-1

Protein Summary
Description
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. This gene encodes a member of the catenin family of proteins that play ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302763
  • ENSP00000304669
  • ENSG00000044115
  • ENST00000540387
  • ENSP00000438476

Symbol
  • MDPT2
  • CAP102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
ligand (protein) perturbation
1
kinase perturbation
0.97
transcription factor perturbation
0.97
biological process
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.28   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.28   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
2
2
64.2
comparative body size at age 10, self-reported
1
1
1
61
5
1
1
1.1
33.1
1
1
0
1.1
33.1
C-reactive protein measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
64.2
comparative body size at age 10, self-reported
1
61
1
1.1
33.1
0
1.1
33.1
C-reactive protein measurement
1
24.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
catenin alpha 1
VGNC:3958
450165
Macaque
catenin alpha 1
574385
Mouse
MGI:88274
12385
Rat
RGD:1359485
307505
Dog
catenin alpha 1
VGNC:51706
474698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
catenin alpha 1
Macaque
catenin alpha 1
Mouse
Rat
Dog
catenin alpha 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35221-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Developmental Biology
Gene Ontology Terms (46)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (237)
1 – 10 of 237
CTNNA2
Tbio
Novelty:  0.00783865
p_int:  0.999999907
p_ni:  9.3e-8
Score:  0.902
Data Source:  BioPlex,Reactome,STRINGDB
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.999887294
p_ni:  0.000112706
Score:  0.919
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.999673601
p_ni:  0.000326399
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
TES
Tbio
Novelty:  0.00052221
p_int:  0.99963929
p_ni:  0.00036071
Score:  0.233
Data Source:  BioPlex,STRINGDB
CTNNBIP1
Tbio
Novelty:  0.05434645
p_int:  0.950811575
p_ni:  0.049188425
Score:  0.245
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.912319896
p_ni:  0.087680104
Data Source:  BioPlex
DMD
Tclin
Novelty:  0.00025661
p_int:  0.894210087
p_ni:  0.105789913
Score:  0.534
Data Source:  BioPlex,STRINGDB
SAPCD1
Tdark
Novelty:  0.90892824
p_int:  0.830566752
p_ni:  0.169433248
Score:  0.199
Data Source:  BioPlex,STRINGDB
SLAMF7
Tclin
Novelty:  0.01014396
p_int:  0.799791588
p_ni:  0.200208412
Score:  0.187
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.999
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  101.28

PubMed score by year
PubTator Score  47.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: