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Tbio
CA8
Carbonic anhydrase-related protein

Protein Summary
Description
Does not have a carbonic anhydrase catalytic activity. The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317995
  • ENSP00000314407
  • ENSG00000178538

Symbol
  • CALS
  • CALS
  • CARP
  • CA-RP
  • CAMRQ3
  • CA-VIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
transcription factor perturbation
0.8
PubMedID
0.71
histone modification site profile
0.7
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.42   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.42   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SERPINA1
Tbio
Novelty:  0.00014098
p_int:  0.999795787
p_ni:  0.000204213
Score:  0.151
Data Source:  BioPlex,STRINGDB
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.999630101
p_ni:  0.000305039
p_wrong:  0.00006486
Data Source:  BioPlex
IGHG3
Tclin
p_int:  0.999383565
p_ni:  0.000067719
p_wrong:  0.000548716
Data Source:  BioPlex
FGG
Tbio
Novelty:  0.00404457
p_int:  0.989646903
p_ni:  0.01034297
p_wrong:  0.000010127
Score:  0.189
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.976077103
p_ni:  0.023922887
p_wrong:  1e-8
Data Source:  BioPlex
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
p_int:  0.972201658
p_ni:  0.027798342
Score:  0.246
Data Source:  BioPlex,STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
p_int:  0.971006779
p_ni:  0.028993221
Score:  0.761
Data Source:  BioPlex,STRINGDB
ALB
Tchem
Novelty:  0.00000616
p_int:  0.969325469
p_ni:  0.030674531
Score:  0.534
Data Source:  BioPlex,STRINGDB
IGLL5
Tbio
Novelty:  0.00459259
p_int:  0.964077358
p_ni:  0.00216023
p_wrong:  0.033762412
Data Source:  BioPlex
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.947497116
p_ni:  0.052502884
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
56.2
thyroxine measurement
1
1
1
52
hemoglobin measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
56.2
thyroxine measurement
1
52
hemoglobin measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 8
VGNC:10215
464196
Macaque
carbonic anhydrase 8
699005
Mouse
MGI:88253
12319
Rat
RGD:1304709
297814
Dog
carbonic anhydrase 8
VGNC:38616
486965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 8
Macaque
carbonic anhydrase 8
Mouse
Rat
Dog
carbonic anhydrase 8
Publication Statistics
PubMed Score 242.42
PubMed score by year
PubTator Score 80.63
PubTator score by year
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Related Publications
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PMID
Year
Title