Tclin CA5A Carbonic anhydrase 5A, mitochondrial

Protein Summary

Description

Reversible hydration of carbon dioxide. Low activity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35218
• B2RPF2

Gene Name

• CA5A

Ensembl ID

• ENST00000309893
• ENSP00000309649
• ENSG00000174990
• ENST00000649794
• ENSP00000498065

Symbol

• CA5
• CA5
• CAV
• CAVA
• CA5AD
• GS1-21A4.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.6
kinase perturbation	0.54
chemical	0.51
disease perturbation	0.49
PubMedID	0.49

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.41   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.41   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 123

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14

Approved Drugs (14)

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1 – 10 of 14

acetazolamide

CA5ATclin Enzyme

Ki: 7.22

ethoxzolamide

CA5ATclin Enzyme

INHIBITOR Ki: 8.7

topiramate

CA5ATclin Enzyme

Kd: 7.59

celecoxib

CA5ATclin Enzyme

Ki: 6.1

dichlorphenamide

CA5ATclin Enzyme

Ki: 7.09

dorzolamide

CA5ATclin Enzyme

Ki: 7.38

brinzolamide

CA5ATclin Enzyme

Ki: 7.3

valdecoxib

CA5ATclin Enzyme

Ki: 6.04

sulpiride

CA5ATclin Enzyme

Ki: 6.76

indapamide

CA5ATclin Enzyme

Ki: 6.05

Active Ligands (123)

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1 – 10 of 123

CHEMBL19

CA5ATclin Enzyme

Ki: 7.19

CHEMBL77517

CA5ATclin Enzyme

Ki: 7.1

CHEMBL750

CA5ATclin Enzyme

Ki: 7.7

CHEMBL268439

CA5ATclin Enzyme

Ki: 7.47

CHEMBL73962

CA5ATclin Enzyme

Ki: 7.43

CHEMBL266026

CA5ATclin Enzyme

Ki: 6.75

CHEMBL7146

CA5ATclin Enzyme

Ki: 6.92

CHEMBL6685

CA5ATclin Enzyme

Ki: 7.27

CHEMBL360356

CA5ATclin Enzyme

Ki: 7.37

CHEMBL2333416

CA5ATclin Enzyme

Kd: 6.48

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil count	EFO_0005090	2	1	2		52.3
basophil percentage of granulocytes	EFO_0007995	1	1	1		35
basophil percentage of leukocytes	EFO_0007992	1	1	1		34.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil count	EFO_0005090	2		52.3
basophil percentage of granulocytes	EFO_0007995	1		35
basophil percentage of leukocytes	EFO_0007992	1		34.7

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Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (5)

Functions (2)

Components (2)

Processes (1)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (25)

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1 – 10 of 25

• See Interactions on String-DB

PMPCA

Tbio

Family: Enzyme

Novelty: 0.01842996

p_int: 0.795404378

p_ni: 0.204595622

Score: 0.195

Data Source: BioPlex,STRINGDB

SIRT3

Tchem

Family: Epigenetic

Novelty: 0.00101187

p_int: 0.758652554

p_ni: 0.241347179

p_wrong: 2.66e-7

Score: 0.214

Data Source: BioPlex,STRINGDB

CYP24A1

Tchem

Family: Enzyme

Novelty: 0.00107155

Score: 0.798

Data Source: STRINGDB

THRSP

Tbio

Novelty: 0.00938864

Score: 0.718

Data Source: STRINGDB

UHMK1

Tbio

Family: Kinase

Novelty: 0.04117277

Score: 0.67

Data Source: STRINGDB

MT-CO3

Tbio

Family: Enzyme

Novelty: 0.00253369

Score: 0.6

Data Source: STRINGDB

SNRPB

Tbio

Novelty: 0.01503535

Score: 0.579

Data Source: STRINGDB

SLC4A4

Tbio

Family: Transporter

Novelty: 0.00352439

Score: 0.549

Data Source: STRINGDB

TXNRD2

Tbio

Family: Enzyme

Novelty: 0.002052

Score: 0.539

Data Source: STRINGDB

SLC9A1

Tchem

Family: Transporter

Novelty: 0.00096678

Score: 0.537

Data Source: STRINGDB

Publication Statistics

PubMed Score  148.41

PubMed score by year

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PubTator Score  182.83

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Direct protein sequencing
Disease mutation
Lyase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc

GWAS Trait Find Similar Targets

basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes

MGI Phenotype Find Similar Targets

growth/size/body region phenotype
homeostasis/metabolism phenotype