CA5A
Carbonic anhydrase 5A, mitochondrial
Protein Summary
Reversible hydration of carbon dioxide. Low activity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
- ENST00000309893
- ENSP00000309649
- ENSG00000174990
- ENST00000649794
- ENSP00000498065
- CA5
- CA5
- CAV
- CAVA
- CA5AD
- GS1-21A4.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.6 | ||
kinase perturbation | 0.54 | ||
chemical | 0.51 | ||
disease perturbation | 0.49 | ||
PubMedID | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.08 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 149.08 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 307
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 17
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (17)
Active Ligands (307)
Protein-Protein Interactions (25)
PMPCA
Family: Enzyme
Novelty: 0.01842996
p_int: 0.795404378
p_ni: 0.204595622
Score: 0.195
Data Source: BioPlex,STRINGDB
SIRT3
Family: Epigenetic
Novelty: 0.00101187
p_int: 0.758652554
p_ni: 0.241347179
p_wrong: 2.66e-7
Score: 0.214
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 2 | 2 | 93.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 86.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 84.9 | |||||
blood metabolite measurement | 1 | 1 | 1 | 77.3 | |||||
testosterone measurement | 2 | 2 | 2 | 77.2 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 93.7 | |||||
mean reticulocyte volume | 1 | 86.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 84.9 | |||||
blood metabolite measurement | 1 | 77.3 | |||||
testosterone measurement | 2 | 77.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 5A | VGNC:9075 | 468095 | |||||
Mouse | MGI:101946 | 12352 | ||||||
Rat | RGD:2243 | 54233 | ||||||
Dog | carbonic anhydrase 5A | VGNC:53312 | 609174 | |||||
Horse | carbonic anhydrase 5A | VGNC:49304 | 100070642 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 5A | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 5A | |||||
Horse | carbonic anhydrase 5A | |||||
Publication Statistics
PubMed Score 149.08
PubMed score by year
PubTator Score 182.83
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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