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Tclin
CA5A
Carbonic anhydrase 5A, mitochondrial

Protein Summary
Description
Reversible hydration of carbon dioxide. Low activity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309893
  • ENSP00000309649
  • ENSG00000174990
  • ENST00000649794
  • ENSP00000498065

Symbol
  • CA5
  • CA5
  • CAV
  • CAVA
  • CA5AD
  • GS1-21A4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.6
kinase perturbation
0.54
chemical
0.51
disease perturbation
0.49
PubMedID
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 307
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (17)
topiramate
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celecoxib
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acetazolamide
Rendered image for acetazolamide
indapamide
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ethoxzolamide
Rendered image for ethoxzolamide
furosemide
Rendered image for furosemide
brinzolamide
Rendered image for brinzolamide
dichlorphenamide
Rendered image for dichlorphenamide
dorzolamide
Rendered image for dorzolamide
rufinamide
Rendered image for rufinamide
Active Ligands (307)
Protein-Protein Interactions (25)
PMPCA
Tbio
Family:  Enzyme
Novelty:  0.01842996
p_int:  0.795404378
p_ni:  0.204595622
Score:  0.195
Data Source:  BioPlex,STRINGDB
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
p_int:  0.758652554
p_ni:  0.241347179
p_wrong:  2.66e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
CYP24A1
Tchem
Family:  Enzyme
Novelty:  0.00107155
Score:  0.798
Data Source:  STRINGDB
THRSP
Tbio
Novelty:  0.00938864
Score:  0.718
Data Source:  STRINGDB
UHMK1
Tbio
Family:  Kinase
Novelty:  0.04117277
Score:  0.67
Data Source:  STRINGDB
MT-CO3
Tbio
Family:  Enzyme
Novelty:  0.00253369
Score:  0.6
Data Source:  STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
Score:  0.579
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.549
Data Source:  STRINGDB
TXNRD2
Tbio
Family:  Enzyme
Novelty:  0.002052
Score:  0.539
Data Source:  STRINGDB
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
Score:  0.537
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
93.7
mean reticulocyte volume
1
1
1
86.3
mean corpuscular hemoglobin concentration
1
1
1
84.9
blood metabolite measurement
1
1
1
77.3
testosterone measurement
2
2
2
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
93.7
mean reticulocyte volume
1
86.3
mean corpuscular hemoglobin concentration
1
84.9
blood metabolite measurement
1
77.3
testosterone measurement
2
77.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 5A
VGNC:9075
468095
Mouse
MGI:101946
12352
Rat
RGD:2243
54233
Dog
carbonic anhydrase 5A
VGNC:53312
609174
Horse
carbonic anhydrase 5A
VGNC:49304
100070642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 5A
Mouse
Rat
Dog
carbonic anhydrase 5A
Horse
carbonic anhydrase 5A
Publication Statistics
PubMed Score 149.08
PubMed score by year
PubTator Score 182.83
PubTator score by year
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Related Publications
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PMID
Year
Title