Tclin CA5A Carbonic anhydrase 5A, mitochondrial

Protein Summary

Description

Reversible hydration of carbon dioxide. Low activity. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35218
• B2RPF2

Gene Name

• CA5A

Ensembl ID

• ENST00000309893
• ENSP00000309649
• ENSG00000174990
• ENST00000649794
• ENSP00000498065

Symbol

• CA5
• CA5
• CAV
• CAVA
• CA5AD
• GS1-21A4.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.6
kinase perturbation	0.54
chemical	0.51
disease perturbation	0.49
PubMedID	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.46   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.46   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 322

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17