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Tbio
PFN2
Profilin-2

Protein Summary
Description
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239940
  • ENSP00000239940
  • ENSG00000070087
  • ENST00000452853
  • ENSP00000410464

Symbol
  • PFL
  • D3S1319E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
gene perturbation
0.96
virus perturbation
0.92
molecular function
0.86
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.17   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.17   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
RHO GTPase Effectors
RHO GTPases Activate Formins
Signal Transduction
Protein-Protein Interactions (110)
1 – 10 of 110
NAA80
Tbio
Family: Enzyme
Novelty: 7
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
INF2
Tbio
Novelty: 0.00549873
p_int: 0.999999885
p_ni: 1.15e-7
Score: 0.793
Data Source: BioPlex,STRINGDB
PALLD
Tbio
Novelty: 0.00174021
p_int: 0.999953612
p_ni: 0.000046387
p_wrong: 1e-9
Score: 0.344
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.998884943
p_ni: 0.001115057
Score: 0.442
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00281551
p_int: 0.997230494
p_ni: 0.002769506
Score: 0.451
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00027728
p_int: 0.99536493
p_ni: 0.00463507
Score: 0.979
Data Source: BioPlex,STRINGDB
DIAPH1
Tbio
Novelty: 0.01645164
p_int: 0.992734706
p_ni: 0.007265294
p_wrong: 1e-9
Score: 0.943
Data Source: BioPlex,STRINGDB
BLVRB
Tbio
Family: Enzyme
Novelty: 0.00428818
p_int: 0.94932726
p_ni: 0.048557553
p_wrong: 0.002115187
Score: 0.204
Data Source: BioPlex,STRINGDB
ENAH
Tbio
Novelty: 0.03560604
p_int: 0.91917266
p_ni: 0.08082734
Score: 0.986
Data Source: BioPlex,STRINGDB
VASP
Tbio
Novelty: 0.00096602
p_int: 0.863762057
p_ni: 0.136237943
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.17

PubMed score by year
PubTator Score  160.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer