Protein Summary
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
- ENST00000342836
- ENSP00000340889
- ENSG00000010438
- ENST00000361005
- ENSP00000354280
- ENST00000379405
- ENSP00000368715
- ENST00000429677
- ENSP00000401828
- PRSS4
- TRY3
- TRY4
- T9
- MTG
- TRY3
- TRY4
- PRSS4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.66 | ||
pathway | 0.58 | ||
protein domain | 0.58 | ||
drug | 0.54 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 348.48 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 340 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 348.48 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 340 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (16)
Protein-Protein Interactions (107)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (14)
Reactome (10)
KEGG (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Alpha-defensins | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defensins | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Alpha-defensins | ||||
Antimicrobial peptides | ||||
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defensins | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 1 | 1 | 83.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 78.1 | |||||
body mass index | 1 | 1 | 1 | 57.8 | |||||
triglyceride measurement | 1 | 1 | 1 | 46.5 | |||||
electrocardiography | 1 | 1 | 23 | 38.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 83.5 | |||||
mean reticulocyte volume | 1 | 78.1 | |||||
body mass index | 1 | 57.8 | |||||
triglyceride measurement | 1 | 46.5 | |||||
electrocardiography | 23 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:102759 | 22072 | ||||||
Dog | protease, serine 2 | 100686744 | ||||||
Horse | anionic trypsin | 100055297 | ||||||
Opossum | anionic trypsin-like | 100010951 | ||||||
Platypus | cationic trypsin-3-like | 100086459 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | protease, serine 2 | |||||
Horse | anionic trypsin | |||||
Opossum | anionic trypsin-like | |||||
Platypus | cationic trypsin-3-like | |||||
Publication Statistics
PubMed Score 348.48
PubMed score by year
PubTator Score 134.19
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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