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Tchem
PRSS3
Trypsin-3

Protein Summary
Description
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342836
  • ENSP00000340889
  • ENSG00000010438
  • ENST00000361005
  • ENSP00000354280
  • ENST00000379405
  • ENSP00000368715
  • ENST00000429677
  • ENSP00000401828

Symbol
  • PRSS4
  • TRY3
  • TRY4
  • T9
  • MTG
  • TRY3
  • TRY4
  • PRSS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
pathway
0.58
protein domain
0.58
drug
0.54
transcription factor perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.65   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.65   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
37.1
grip strength measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
37.1
grip strength measurement
1
16.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102759
22072
Dog
protease, serine 2
100686744
Horse
anionic trypsin
100055297
Opossum
anionic trypsin-like
100010951
Platypus
cationic trypsin-3-like
100086459
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
protease, serine 2
Horse
anionic trypsin
Opossum
anionic trypsin-like
Platypus
cationic trypsin-3-like
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defensins
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defensins
Immune System
Protein-Protein Interactions (107)
1 – 10 of 107
SPTAN1
Tbio
Novelty: 0.00286901
Score: 0.928
Data Source: STRINGDB
C6orf15
Tdark
Novelty: 0.00402472
Score: 0.921
Data Source: STRINGDB
CTSD
Tchem
Family: Enzyme
Novelty: 0.00029823
Score: 0.916
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.916
Data Source: STRINGDB
HP
Tbio
Novelty: 0.00016649
Score: 0.913
Data Source: STRINGDB
CNN2
Tbio
Novelty: 0.02486182
Score: 0.909
Data Source: STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.908
Data Source: STRINGDB
LRG1
Tbio
Novelty: 0.00445522
Score: 0.906
Data Source: STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
Score: 0.905
Data Source: STRINGDB
FTH1
Tbio
Novelty: 0.000863
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  340.65

PubMed score by year
PubTator Score  134.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer