Tclin CRHR1 Corticotropin-releasing factor receptor 1

Protein Summary

Description

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• P34998
• B4DIE9
• Q13008
• Q4QRJ1
• Q9UK64
• CRF-R-1

Gene Name

• CRHR1

Ensembl ID

• ENST00000314537
• ENSP00000326060
• ENSG00000120088
• ENST00000352855
• ENSP00000344068
• ENST00000398285
• ENSP00000381333
• ENST00000577353
• ENSP00000462016
• ENST00000616274
• ENSP00000480396
• ENSG00000276191
• ENST00000616748
• ENSP00000478177
• ENST00000617905
• ENSP00000483802
• ENST00000633723
• ENSP00000488342

Symbol

• CRFR
• CRFR1
• CRHR
• MGC57346-CRHR1
• CRHR1-IT1-CRHR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
co-expressed gene	1
disease	0.77
phenotype	0.77
biological term	0.7

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Corticotropin-releasing Factor Receptor / Corticotropin-releasing Factor Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.03   (req: < 5)

Gene RIFs: 213   (req: <= 3)

Antibodies: 480   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.03   (req: >= 5)

Gene RIFs: 213   (req: > 3)

Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1285

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1