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Tclin
PTGER1
Prostaglandin E2 receptor EP1 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292513
  • ENSP00000292513
  • ENSG00000160951

Symbol
  • EP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.83
phenotype
0.76
protein domain
0.73
cell type or tissue
0.69
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.97   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.97   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 445
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
89.8
myeloid white cell count
1
1
1
71.2
lymphocyte count
1
1
1
70.5
leukocyte count
1
1
1
67.7
reticulocyte count
2
1
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
89.8
myeloid white cell count
1
71.2
lymphocyte count
1
70.5
leukocyte count
1
67.7
reticulocyte count
2
65.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97793
19216
Rat
RGD:3434
25637
Dog
prostaglandin E receptor 1
VGNC:45142
100855637
Cow
prostaglandin E receptor 1
VGNC:33501
507437
Opossum
prostaglandin E receptor 1
100026455
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
prostaglandin E receptor 1
Cow
prostaglandin E receptor 1
Opossum
prostaglandin E receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34995-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (198)
1 – 10 of 198
ADRB2
Tclin
Family:  GPCR
Novelty:  0.00041821
Score:  0.949
Data Source:  STRINGDB
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
Score:  0.946
Data Source:  STRINGDB
LTB4R2
Tchem
Family:  GPCR
Novelty:  0.01094048
Score:  0.942
Data Source:  STRINGDB
CYSLTR1
Tclin
Family:  GPCR
Novelty:  0.00337777
Score:  0.941
Data Source:  STRINGDB
PTGFR
Tclin
Family:  GPCR
Novelty:  0.00560908
Score:  0.94
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.938
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.936
Data Source:  STRINGDB
CYSLTR2
Tchem
Family:  GPCR
Novelty:  0.00895224
Score:  0.935
Data Source:  STRINGDB
UTS2R
Tchem
Family:  GPCR
Novelty:  0.00865846
Score:  0.934
Data Source:  STRINGDB
LTB4R
Tchem
Family:  GPCR
Novelty:  0.00354427
Score:  0.933
Data Source:  STRINGDB
Publication Statistics
PubMed Score  718.97

PubMed score by year
PubTator Score  250.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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