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Tbio
OR1D2
Olfactory receptor 1D2

Protein Summary
Description
Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331459
  • ENSP00000327585
  • ENSG00000184166
  • ENST00000641064
  • ENSP00000493077
  • ENST00000641833
  • ENSP00000493103

Symbol
  • OLFR1
  • OLFR1
  • OR17-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.61
tissue
0.51
cell type or tissue
0.45
chemical
0.43
protein domain
0.41


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.33   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.33   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3030246
258153
Rat
RGD:1333845
287517
Dog
olfactory receptor 1D2
611352
Horse
olfactory receptor 1D2
100072547
Cow
olfactory receptor 1D2
618593
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
olfactory receptor 1D2
Horse
olfactory receptor 1D2
Cow
olfactory receptor 1D2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34982-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (28)
1 – 10 of 28
RTP2
Tbio
Novelty: 0.05972678
Score: 0.948
Data Source: STRINGDB
GNAL
Tbio
Novelty: 0.01757098
Score: 0.925
Data Source: STRINGDB
RTP1
Tbio
Novelty: 0.0278378
Score: 0.916
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.905
Data Source: STRINGDB
REEP1
Tbio
Novelty: 0.02280713
Score: 0.904
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.903
Data Source: STRINGDB
REEP5
Tbio
Novelty: 0.00160455
Score: 0.9
Data Source: STRINGDB
RTP4
Tbio
Novelty: 0.05959975
Score: 0.9
Data Source: STRINGDB
REEP3
Tbio
Novelty: 0.19673119
Score: 0.9
Data Source: STRINGDB
RTP5
Tdark
Novelty: 0.21798595
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.33

PubMed score by year
PubTator Score  33.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer