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Tclin
TRHR
Thyrotropin-releasing hormone receptor

Protein Summary
Description
Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311762
  • ENSP00000309818
  • ENSG00000174417
  • ENST00000518632
  • ENSP00000430711

Symbol
  • TRH-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.76
tissue sample
0.67
trait
0.61
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.18   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.18   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (190)
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.904532663
p_ni:  0.095467284
p_wrong:  5.3e-8
Score:  0.519
Data Source:  BioPlex,STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.992
Data Source:  STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.966
Data Source:  STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.961
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.943
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.936
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.929
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.927
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.925
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
57.8
lean body mass
1
1
1
39.6
2
2
1
1
21.4
intelligence
1
1
1
1.7
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
57.8
lean body mass
1
39.6
1
1
21.4
intelligence
1
1.7
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone receptor
VGNC:14606
472842
Macaque
thyrotropin releasing hormone receptor
698511
Mouse
MGI:98824
22045
Rat
RGD:3904
25570
Dog
thyrotropin releasing hormone receptor
VGNC:47799
482007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone receptor
Macaque
thyrotropin releasing hormone receptor
Mouse
Rat
Dog
thyrotropin releasing hormone receptor
Publication Statistics
PubMed Score 85.18
PubMed score by year
PubTator Score 71.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title