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Tclin
TRHR
Thyrotropin-releasing hormone receptor

Protein Summary
Description
Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311762
  • ENSP00000309818
  • ENSG00000174417
  • ENST00000518632
  • ENSP00000430711

Symbol
  • TRH-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.76
tissue sample
0.67
trait
0.61
cell line
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.98   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.98   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lean body mass
1
1
1
73.8
pulse pressure measurement
1
1
1
46.6
2
2
1
1
40.1
intelligence
1
1
1
1.4
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lean body mass
1
73.8
pulse pressure measurement
1
46.6
1
1
40.1
intelligence
1
1.4
1
1.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone receptor
VGNC:14606
472842
Macaque
thyrotropin releasing hormone receptor
698511
Mouse
MGI:98824
22045
Rat
RGD:3904
25570
Dog
thyrotropin releasing hormone receptor
VGNC:47799
482007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone receptor
Macaque
thyrotropin releasing hormone receptor
Mouse
Rat
Dog
thyrotropin releasing hormone receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34981-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (190)
1 – 10 of 190
ACP2
Tbio
Family: Enzyme
Novelty: 0.00355652
p_int: 0.904532663
p_ni: 0.095467284
p_wrong: 5.3e-8
Score: 0.519
Data Source: BioPlex,STRINGDB
TRH
Tbio
Novelty: 0.00052673
Score: 0.992
Data Source: STRINGDB
GNRHR
Tclin
Family: GPCR
Novelty: 0.00203671
Score: 0.966
Data Source: STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.961
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.943
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.936
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.929
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.927
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.925
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.00159196
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.98

PubMed score by year
PubTator Score  71.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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