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Tchem
CNR2
Cannabinoid receptor 2

Protein Summary
Description
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374472
  • ENSP00000363596
  • ENSG00000188822

Symbol
  • CB2A
  • CB2B
  • CB2
  • CX5
  • CB-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
cell type or tissue
0.73
chemical
0.68
disease perturbation
0.68
ligand (chemical)
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.95   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.95   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2520
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
87.6
eosinophil percentage of leukocytes
2
2
2
61.7
lymphocyte count
1
1
1
30.2
monocyte count
1
1
1
30.2
eosinophil percentage of granulocytes
1
1
1
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
87.6
eosinophil percentage of leukocytes
2
61.7
lymphocyte count
1
30.2
monocyte count
1
30.2
eosinophil percentage of granulocytes
1
17.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cannabinoid receptor 2
VGNC:6114
456625
Macaque
cannabinoid receptor 2
711155
Mouse
MGI:104650
12802
Rat
RGD:619713
57302
Dog
cannabinoid receptor 2
VGNC:39427
612289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cannabinoid receptor 2
Macaque
cannabinoid receptor 2
Mouse
Rat
Dog
cannabinoid receptor 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (281)
1 – 10 of 281
GPR55
Tclin
Family: GPCR
Novelty: 0.00428199
Score: 0.979
Data Source: STRINGDB
GPR18
Tchem
Family: GPCR
Novelty: 0.0178347
Score: 0.965
Data Source: STRINGDB
OPRD1
Tclin
Family: GPCR
Novelty: 0.00757692
Score: 0.965
Data Source: STRINGDB
OPRL1
Tchem
Family: GPCR
Novelty: 0.00186729
Score: 0.963
Data Source: STRINGDB
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.951
Data Source: STRINGDB
DRD3
Tclin
Family: GPCR
Novelty: 0.00230028
Score: 0.95
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.949
Data Source: STRINGDB
HTR1A
Tclin
Family: GPCR
Novelty: 0.00015658
Score: 0.94
Data Source: STRINGDB
ADRA2C
Tclin
Family: GPCR
Novelty: 0.00661399
Score: 0.934
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  461.95

PubMed score by year
PubTator Score  905.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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