Tchem CNR2 Cannabinoid receptor 2

Protein Summary

Description

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P34972
• C6ES44
• Q4VBK8
• Q5JRH7
• Q6B0G7
• Q6NSY0
• CB-2

Gene Name

• CNR2

Ensembl ID

• ENST00000374472
• ENSP00000363596
• ENSG00000188822

Symbol

• CB2A
• CB2B
• CB2
• CX5
• CB-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.82
cell type or tissue	0.73
chemical	0.68
disease perturbation	0.68
ligand (chemical)	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cannabinoid Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Cannabinoid Receptor / Cannabinoid Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.31   (req: < 5)

Gene RIFs: 240   (req: <= 3)

Antibodies: 428   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.31   (req: >= 5)

Gene RIFs: 240   (req: > 3)

Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3443

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3