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Tchem
MPI
Mannose-6-phosphate isomerase

Protein Classes
Protein Summary
Description
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323744
  • ENSP00000318192
  • ENSG00000178802
  • ENST00000352410
  • ENSP00000318318

Symbol
  • PMI1
  • PMI
  • PMI1
  • CDG1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.9
kinase perturbation
0.76
gene perturbation
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
70.4
1
1
1
34.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
70.4
1
34.2
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannose phosphate isomerase
VGNC:1913
453748
Mouse
MGI:97075
110119
Rat
RGD:3107
300741
Dog
mannose phosphate isomerase [Source:HGNC Symbol;Acc:HGNC:7216]
Horse
mannose phosphate isomerase
VGNC:20286
100062077
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannose phosphate isomerase
Mouse
Rat
Dog
mannose phosphate isomerase [Source:HGNC Symbol;Acc:HGNC:7216]
Horse
mannose phosphate isomerase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34949-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective MPI causes MPI-CDG (CDG-1b)
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective MPI causes MPI-CDG (CDG-1b)
Disease
Diseases associated with glycosylation precursor biosynthesis
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (135)
1 – 10 of 135
SERPINA3
Tbio
Novelty: 0.00134253
p_int: 0.861230078
p_ni: 0.138666088
p_wrong: 0.000103834
Score: 0.379
Data Source: BioPlex,STRINGDB
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.848257382
p_ni: 0.151742618
Score: 0.169
Data Source: BioPlex,STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00103799
p_int: 0.825690098
p_ni: 0.174309898
p_wrong: 4e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.993
Data Source: STRINGDB
PMM2
Tchem
Family: Enzyme
Novelty: 0.01177513
Score: 0.987
Data Source: STRINGDB
PMM1
Tbio
Family: Enzyme
Novelty: 0.03310193
Score: 0.974
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00195554
Score: 0.97
Data Source: STRINGDB
GFPT1
Tchem
Family: Enzyme
Novelty: 0.00358283
Score: 0.955
Data Source: STRINGDB
GFPT2
Tbio
Family: Enzyme
Novelty: 0.01049877
Score: 0.948
Data Source: STRINGDB
HKDC1
Tbio
Family: Kinase
Novelty: 0.016969
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.58

PubMed score by year
PubTator Score  151.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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