GRK5
G protein-coupled receptor kinase 5
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
disease perturbation | 0.95 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.86 | ||
chemical bioactivity profile | 0.71 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | G alpha (q) signalling events | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
G alpha (q) signalling events | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CACAO | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
CCL17 measurement | 1 | 1 | 1 | 86.5 | |||||
mean platelet volume | 3 | 1 | 3 | 85.4 | |||||
platelet aggregation | 1 | 1 | 1 | 82.8 | |||||
3 | 1 | 1 | 1.1 | 70.2 | |||||
lymphocyte count | 2 | 1 | 2 | 66 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
CCL17 measurement | 1 | 86.5 | |||||
mean platelet volume | 3 | 85.4 | |||||
platelet aggregation | 1 | 82.8 | |||||
1 | 1.1 | 70.2 | |||||
lymphocyte count | 2 | 66 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 5 | VGNC:4700 | 466217 | |||||
Macaque | G protein-coupled receptor kinase 5 | 100427251 | ||||||
Mouse | MGI:109161 | 14773 | ||||||
Rat | RGD:61985 | 59075 | ||||||
Dog | G protein-coupled receptor kinase 5 | VGNC:41505 | 486915 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 5 | |||||
Macaque | G protein-coupled receptor kinase 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein-coupled receptor kinase 5 | |||||
PMID | Year | Title |
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