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Tchem
EPHX2
Bifunctional epoxide hydrolase 2

Protein Summary
Description
Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380476
  • ENSP00000369843
  • ENSG00000120915
  • ENST00000521400
  • ENSP00000430269
  • ENST00000521780
  • ENSP00000430302

Symbol
  • CEH
  • SEH
  • ABHD20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.96
gene perturbation
0.95
protein domain
0.92
chemical
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.17   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.17   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1561
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1561)
Ebselen
Rendered image for Ebselen
diflapolin
Rendered image for diflapolin
CHEMBL551921
Rendered image for CHEMBL551921
CHEMBL561788
Rendered image for CHEMBL561788
CHEMBL552402
Rendered image for CHEMBL552402
CHEMBL552061
Rendered image for CHEMBL552061
dual sEH/FAAH inhibitor 11
Rendered image for dual sEH/FAAH inhibitor 11
PF750
Rendered image for PF750
CHEMBL4215208
Rendered image for CHEMBL4215208
Protein-Protein Interactions (137)
CYP2J2
Tchem
Novelty:  0.00534181
Score:  0.967
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.953
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.951
Data Source:  STRINGDB
CYP2C8
Tchem
Novelty:  0.00186373
Score:  0.949
Data Source:  STRINGDB
GSTK1
Tchem
Family:  Enzyme
Novelty:  0.04205366
Score:  0.947
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.944
Data Source:  STRINGDB
SCP2
Tchem
Novelty:  0.00183736
Score:  0.944
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.934
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.928
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
ALOX5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (53)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresins
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresins
Biosynthesis of specialized proresolving mediators (SPMs)
Fatty acid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
4
5
96.8
smoking initiation
4
5
5
94.8
6
4
0
5.9
91.7
family history of Alzheimer’s disease
1
3
0
8.3
87.3
cigarettes per day measurement
4
4
5
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
5
96.8
smoking initiation
5
94.8
0
5.9
91.7
family history of Alzheimer’s disease
0
8.3
87.3
cigarettes per day measurement
5
77.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epoxide hydrolase 2
VGNC:11967
464074
Macaque
epoxide hydrolase 2
712926
Mouse
MGI:99500
13850
Rat
RGD:620732
65030
Dog
epoxide hydrolase 2
VGNC:40416
477373
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epoxide hydrolase 2
Macaque
epoxide hydrolase 2
Mouse
Rat
Dog
epoxide hydrolase 2
Publication Statistics
PubMed Score 230.17
PubMed score by year
PubTator Score 421.80
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title