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Tclin
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370314
  • ENSP00000359337
  • ENSG00000011677
  • ENST00000535043
  • ENSP00000443527
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.96
protein domain
0.92
gene perturbation
0.91
molecular function
0.9


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.91   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.91   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 27
Approved Drugs (27)
1 – 10 of 27
halothane
chemical structure image
isoflurane
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
methoxyflurane
chemical structure image
metharbital
chemical structure image
talbutal
chemical structure image
triclofos
chemical structure image
thiamylal
chemical structure image
halazepam
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor alpha3 subunit
711230
Mouse
MGI:95615
14396
Rat
RGD:2648
24947
Dog
gamma-aminobutyric acid type A receptor alpha3 subunit
VGNC:41055
492223
Horse
gamma-aminobutyric acid type A receptor alpha3 subunit
VGNC:18193
100063420
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor alpha3 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor alpha3 subunit
Horse
gamma-aminobutyric acid type A receptor alpha3 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34903-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
p_int: 0.999999941
p_wrong: 5.9e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
ABCA7
Tbio
Family: Transporter
Novelty: 0.00808369
p_int: 0.998360459
p_ni: 0.001347275
p_wrong: 0.000292265
Score: 0.195
Data Source: BioPlex,STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.997889371
p_ni: 0.000931606
p_wrong: 0.001179022
Score: 0.223
Data Source: BioPlex,STRINGDB
TMEM131
Tdark
Novelty: 0.02152783
p_int: 0.99352543
p_ni: 0.00647457
Data Source: BioPlex
GLRB
Tclin
Family: IC
Novelty: 0.01721113
p_int: 0.993368449
p_ni: 0.006576581
p_wrong: 0.00005497
Score: 0.642
Data Source: BioPlex,STRINGDB
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.991217702
p_ni: 0.008652115
p_wrong: 0.000130183
Score: 0.152
Data Source: BioPlex,STRINGDB
AMIGO1
Tbio
Novelty: 0.00864791
p_int: 0.981583319
p_ni: 0.018395603
p_wrong: 0.000021079
Data Source: BioPlex
TMEM59L
Tbio
Novelty: 0.22745646
p_int: 0.978260685
p_ni: 0.01948075
p_wrong: 0.002258566
Score: 0.248
Data Source: BioPlex,STRINGDB
TTC17
Tdark
Novelty: 0.79373597
p_int: 0.967403573
p_ni: 0.032596427
Data Source: BioPlex
EDA
Tbio
Novelty: 0.00352464
p_int: 0.965038662
p_ni: 0.009515138
p_wrong: 0.0254462
Score: 0.216
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.91

PubMed score by year
PubTator Score  34.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer