You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SHMT2
Serine hydroxymethyltransferase, mitochondrial

Protein Summary
Description
Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:25619277). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640, PubMed:29364879). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitinat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328923
  • ENSP00000333667
  • ENSG00000182199
  • ENST00000414700
  • ENSP00000406881
  • ENST00000449049
  • ENSP00000413770
  • ENST00000553474
  • ENSP00000452419
  • ENST00000557487
  • ENSP00000452315

Symbol
  • GLYA
  • SHMT
  • HEL-S-51e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
disease perturbation
0.93
cellular component
0.87
pathway
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.99   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.99   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (234)
1 – 10 of 234
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00263085
p_int: 0.99999968
p_ni: 3.2e-7
Score: 0.867
Data Source: BioPlex,STRINGDB
ABRAXAS2
Tbio
Novelty: 0.30679328
p_int: 0.999874042
p_ni: 0.000125958
Score: 0.976
Data Source: BioPlex,STRINGDB
BABAM2
Tbio
Novelty: 0.00474508
p_int: 0.999671211
p_ni: 0.000328789
Score: 0.987
Data Source: BioPlex,STRINGDB
BABAM1
Tbio
Novelty: 0.05690582
p_int: 0.998180388
p_ni: 0.001819612
Score: 0.991
Data Source: BioPlex,STRINGDB
TMEM184A
Tbio
Novelty: 0.18808777
p_int: 0.970302276
p_ni: 0.029697724
Score: 0.175
Data Source: BioPlex,STRINGDB
BRCC3
Tbio
Family: Enzyme
Novelty: 0.06615415
p_int: 0.955690995
p_ni: 0.044309005
Score: 0.997
Data Source: BioPlex,STRINGDB
GART
Tclin
Novelty: 0.00353084
Score: 0.997
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00643735
Score: 0.993
Data Source: STRINGDB
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.02582903
Score: 0.993
Data Source: STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.01431753
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  238.99

PubMed score by year
PubTator Score  68.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer