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Tbio
SHMT1
Serine hydroxymethyltransferase, cytosolic

Protein Summary
Description
Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160). This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316694
  • ENSP00000318868
  • ENSG00000176974
  • ENST00000352886
  • ENSP00000345881
  • ENST00000354098
  • ENSP00000318805

Symbol
  • SHMT
  • CSHMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.88
molecular function
0.86
interacting protein
0.77
tissue sample
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.54   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.54   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine hydroxymethyltransferase 1
VGNC:9609
454490
Macaque
serine hydroxymethyltransferase 1
701186
Mouse
MGI:98299
20425
Rat
RGD:1312011
287379
Dog
serine hydroxymethyltransferase 1
VGNC:46150
489536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine hydroxymethyltransferase 1
Macaque
serine hydroxymethyltransferase 1
Mouse
Rat
Dog
serine hydroxymethyltransferase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P34896-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Carnitine synthesis (R-HSA-71262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carnitine synthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Carnitine synthesis
Metabolism
Metabolism of amino acids and derivatives
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Gene Ontology Terms (30)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (193)
1 – 10 of 193
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
p_int: 0.99999968
p_ni: 3.2e-7
Score: 0.867
Data Source: BioPlex,STRINGDB
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
p_int: 0.987704676
p_ni: 0.012295324
Score: 0.312
Data Source: BioPlex,STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00183071
p_int: 0.94955938
p_ni: 0.05044062
Score: 0.226
Data Source: BioPlex,STRINGDB
BMT2
Tbio
Family: Enzyme
Novelty: 0.05916379
p_int: 0.809605927
p_ni: 0.190394073
Score: 0.188
Data Source: BioPlex,STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.997
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.995
Data Source: STRINGDB
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.01776594
Score: 0.991
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.991
Data Source: STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
Score: 0.99
Data Source: STRINGDB
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.18530504
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  475.54

PubMed score by year
PubTator Score  144.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer