Protein Summary
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
- ENST00000302190
- ENSP00000307046
- ENSG00000169439
- HSPG1
- HSPG
- CD362
- HSPG1
- SYND2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.99 | ||
small molecule perturbation | 0.92 | ||
microRNA | 0.84 | ||
disease | 0.81 | ||
PubMedID | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.59 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.59 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (305)
DHRS2
Family: Enzyme
Novelty: 0.002032
p_int: 0.999999758
p_ni: 2.38e-7
p_wrong: 3e-9
Data Source: BioPlex
GPR183
Family: GPCR
Novelty: 0.02005679
p_int: 0.999999681
p_ni: 3.18e-7
p_wrong: 1e-9
Data Source: BioPlex
FGF2
Novelty: 0.00007856
p_int: 0.999999424
p_ni: 5.61e-7
p_wrong: 1.5e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
PDPK1
Family: Kinase
Novelty: 0.00430458
p_int: 0.999997992
p_ni: 0.000002008
Data Source: BioPlex
GMEB1
Family: TF
Novelty: 0.10522678
p_int: 0.999994638
p_ni: 0.000005362
Score: 0.306
Data Source: BioPlex,STRINGDB
PRDM10
Family: TF; Epigenetic
Novelty: 0.03463517
p_int: 0.999985181
p_ni: 0.000014819
Data Source: BioPlex
GMEB2
Family: TF
Novelty: 0.1945427
p_int: 0.999984244
p_ni: 0.000015237
p_wrong: 5.19e-7
Score: 0.306
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999968009
p_ni: 0.000031991
Data Source: BioPlex
SNX33
Novelty: 0.11762505
p_int: 0.999952833
p_ni: 0.000046983
p_wrong: 1.84e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
SULF1
Family: Enzyme
Novelty: 0.00992209
p_int: 0.999944592
p_ni: 0.000055169
p_wrong: 2.39e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (90)
Reactome (37)
KEGG (4)
PathwayCommons (14)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Axon guidance | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Axon guidance | ||||
Cell surface interactions at the vascular wall | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (7)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 1 | 1 | 1 | 63.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 1 | 63.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syndecan 2 | VGNC:801 | 464297 | |||||
Macaque | syndecan 2 | 703841 | ||||||
Mouse | MGI:1349165 | 15529 | ||||||
Rat | RGD:3649 | 25615 | ||||||
Dog | syndecan 2 | VGNC:54120 | 477945 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syndecan 2 | |||||
Macaque | syndecan 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syndecan 2 | |||||
Publication Statistics
PubMed Score 196.59
PubMed score by year
PubTator Score 342.18
PubTator score by year
Related Publications
Text Mined References (120)
GeneRif Annotations (70)
Items per page:
0 of 0
PMID | Year | Title |
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