Tbio SDC2 Syndecan-2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Syndecan-2

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Syndecan-2

Protein / Defense/immunity Protein / Syndecan-2

Protein / Cytoskeletal Protein / Syndecan-2

Protein / Cell Adhesion Molecule / Syndecan-2

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P34741
• B3KQA3
• Q6PIS6
• Q9H6V1
• SYND2

Gene Name

• SDC2

Ensembl ID

• ENST00000302190
• ENSP00000307046
• ENSG00000169439

Symbol

• HSPG1
• HSPG
• CD362
• HSPG1
• SYND2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
small molecule perturbation	0.92
microRNA	0.84
disease	0.81
PubMedID	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.06   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.06   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (90)

Reactome (37)

KEGG (4)

PathwayCommons (14)

WikiPathways (35)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 37

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Axon guidance	533 targets	R-HSA-422475
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Gene Ontology Terms (18)

Functions (2)

Components (7)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
PDZ domain binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (305)

Explore Interacting Targets

1 – 10 of 305

• See Interactions on String-DB

DHRS2

Tbio

Family: Enzyme

Novelty: 0.00319535

p_int: 0.999999758

p_ni: 2.38e-7

p_wrong: 3e-9

Data Source: BioPlex

GPR183

Tchem

Family: GPCR

Novelty: 0.021257

p_int: 0.999999681

p_ni: 3.18e-7

p_wrong: 1e-9

Data Source: BioPlex

FGF2

Tchem

Novelty: 0.00009754

p_int: 0.999999424

p_ni: 5.61e-7

p_wrong: 1.5e-8

Score: 0.974

Data Source: BioPlex,STRINGDB

PDPK1

Tchem

Family: Kinase

Novelty: 0.00422868

p_int: 0.999997992

p_ni: 0.000002008

Data Source: BioPlex

GMEB1

Tbio

Family: TF

Novelty: 0.12195122

p_int: 0.999994638

p_ni: 0.000005362

Score: 0.306

Data Source: BioPlex,STRINGDB

PRDM10

Tbio

Family: TF; Epigenetic

Novelty: 0.00009655

p_int: 0.999985181

p_ni: 0.000014819

Data Source: BioPlex

GMEB2

Tdark

Family: TF

Novelty: 0.2732596

p_int: 0.999984244

p_ni: 0.000015237

p_wrong: 5.19e-7

Score: 0.306

Data Source: BioPlex,STRINGDB

CAMKV

Tbio

Family: Kinase

Novelty: 0.02297481

p_int: 0.999968009

p_ni: 0.000031991

Data Source: BioPlex

SNX33

Tbio

Novelty: 0.3156708

p_int: 0.999952833

p_ni: 0.000046983

p_wrong: 1.84e-7

Score: 0.162

Data Source: BioPlex,STRINGDB

SULF1

Tbio

Family: Enzyme

Novelty: 0.01159942

p_int: 0.999944592

p_ni: 0.000055169

p_wrong: 2.39e-7

Score: 0.439

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  140.06

PubMed score by year

Reset Zoom

PubTator Score  342.18

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Complete proteome
Differentiation
Glycoprotein
Heparan sulfate
Membrane
Neurogenesis
Phosphoprotein
Polymorphism
Proteoglycan
Reference proteome

GWAS Trait Find Similar Targets

type II diabetes mellitus

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
integument phenotype
pigmentation phenotype
vision/eye phenotype