Tbio SDC2 Syndecan-2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Syndecan-2

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Syndecan-2

Protein / Defense/immunity Protein / Syndecan-2

Protein / Cytoskeletal Protein / Syndecan-2

Protein / Cell Adhesion Molecule / Syndecan-2

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Syndecan-2

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P34741
• B3KQA3
• Q6PIS6
• Q9H6V1
• SYND2

Gene Name

• SDC2

Ensembl ID

• ENST00000302190
• ENSP00000307046
• ENSG00000169439

Symbol

• HSPG1
• HSPG
• CD362
• HSPG1
• SYND2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
small molecule perturbation	0.92
microRNA	0.84
disease	0.81
PubMedID	0.81

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.81   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.81   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syndecan 2	VGNC:801	464297
Macaque	syndecan 2		703841
Mouse	syndecan 2	MGI:1349165	15529
Rat	syndecan 2	RGD:3649	25615
Dog	syndecan 2	VGNC:54120	477945

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syndecan 2
Macaque	syndecan 2
Mouse	syndecan 2
Rat	syndecan 2
Dog	syndecan 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P34741-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (90)

Reactome (37)

KEGG (4)

PathwayCommons (14)

WikiPathways (35)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

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Items per page:

5

1 – 5 of 37

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Axon guidance	533 targets	R-HSA-422475
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Gene Ontology Terms (18)

Functions (2)

Components (7)

Processes (9)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
PDZ domain binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (305)

Explore Interacting Targets

1 – 10 of 305

• See Interactions on String-DB

DHRS2

Tbio

Family: Enzyme

Novelty: 0.002032

p_int: 0.999999758

p_ni: 2.38e-7

p_wrong: 3e-9

Data Source: BioPlex

GPR183

Tchem

Family: GPCR

Novelty: 0.02005679

p_int: 0.999999681

p_ni: 3.18e-7

p_wrong: 1e-9

Data Source: BioPlex

FGF2

Tchem

Novelty: 0.00007856

p_int: 0.999999424

p_ni: 5.61e-7

p_wrong: 1.5e-8

Score: 0.974

Data Source: BioPlex,STRINGDB

PDPK1

Tchem

Family: Kinase

Novelty: 0.00430458

p_int: 0.999997992

p_ni: 0.000002008

Data Source: BioPlex

GMEB1

Tbio

Family: TF

Novelty: 0.10522678

p_int: 0.999994638

p_ni: 0.000005362

Score: 0.306

Data Source: BioPlex,STRINGDB

PRDM10

Tbio

Family: TF; Epigenetic

Novelty: 0.03463517

p_int: 0.999985181

p_ni: 0.000014819

Data Source: BioPlex

GMEB2

Tdark

Family: TF

Novelty: 0.1945427

p_int: 0.999984244

p_ni: 0.000015237

p_wrong: 5.19e-7

Score: 0.306

Data Source: BioPlex,STRINGDB

CAMKV

Tbio

Family: Kinase

Novelty: 0.17794181

p_int: 0.999968009

p_ni: 0.000031991

Data Source: BioPlex

SNX33

Tbio

Novelty: 0.11762505

p_int: 0.999952833

p_ni: 0.000046983

p_wrong: 1.84e-7

Score: 0.162

Data Source: BioPlex,STRINGDB

SULF1

Tbio

Family: Enzyme

Novelty: 0.00992209

p_int: 0.999944592

p_ni: 0.000055169

p_wrong: 2.39e-7

Score: 0.439

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  185.81

PubMed score by year

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PubTator Score  342.18

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
Differentiation
Glycoprotein
Heparan sulfate
Membrane
Neurogenesis
Phosphoprotein
Polymorphism
Proteoglycan
Reference proteome

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
integument phenotype
pigmentation phenotype
vision/eye phenotype