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Tbio
SDC2
Syndecan-2

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302190
  • ENSP00000307046
  • ENSG00000169439

Symbol
  • HSPG1
  • HSPG
  • CD362
  • HSPG1
  • SYND2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
small molecule perturbation
0.92
microRNA
0.84
disease
0.81
PubMedID
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.81   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.81   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syndecan 2
VGNC:801
464297
Macaque
syndecan 2
703841
Mouse
MGI:1349165
15529
Rat
RGD:3649
25615
Dog
syndecan 2
VGNC:54120
477945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syndecan 2
Macaque
syndecan 2
Mouse
Rat
Dog
syndecan 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P34741-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (90)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Axon guidance
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (305)
1 – 10 of 305
DHRS2
Tbio
Family: Enzyme
Novelty: 0.002032
p_int: 0.999999758
p_ni: 2.38e-7
p_wrong: 3e-9
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.999999681
p_ni: 3.18e-7
p_wrong: 1e-9
Data Source: BioPlex
FGF2
Tchem
Novelty: 0.00007856
p_int: 0.999999424
p_ni: 5.61e-7
p_wrong: 1.5e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
PDPK1
Tchem
Family: Kinase
Novelty: 0.00430458
p_int: 0.999997992
p_ni: 0.000002008
Data Source: BioPlex
GMEB1
Tbio
Family: TF
Novelty: 0.10522678
p_int: 0.999994638
p_ni: 0.000005362
Score: 0.306
Data Source: BioPlex,STRINGDB
PRDM10
Tbio
Family: TF; Epigenetic
Novelty: 0.03463517
p_int: 0.999985181
p_ni: 0.000014819
Data Source: BioPlex
GMEB2
Tdark
Family: TF
Novelty: 0.1945427
p_int: 0.999984244
p_ni: 0.000015237
p_wrong: 5.19e-7
Score: 0.306
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999968009
p_ni: 0.000031991
Data Source: BioPlex
SNX33
Tbio
Novelty: 0.11762505
p_int: 0.999952833
p_ni: 0.000046983
p_wrong: 1.84e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
SULF1
Tbio
Family: Enzyme
Novelty: 0.00992209
p_int: 0.999944592
p_ni: 0.000055169
p_wrong: 2.39e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  185.81

PubMed score by year
PubTator Score  342.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer