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Tbio
SDC2
Syndecan-2

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302190
  • ENSP00000307046
  • ENSG00000169439

Symbol
  • HSPG1
  • HSPG
  • CD362
  • HSPG1
  • SYND2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
small molecule perturbation
0.92
microRNA
0.84
disease
0.81
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.06   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.06   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (90)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Axon guidance
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (305)
1 – 10 of 305
DHRS2
Tbio
Family: Enzyme
Novelty: 0.00319535
p_int: 0.999999758
p_ni: 2.38e-7
p_wrong: 3e-9
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.021257
p_int: 0.999999681
p_ni: 3.18e-7
p_wrong: 1e-9
Data Source: BioPlex
FGF2
Tchem
Novelty: 0.00009754
p_int: 0.999999424
p_ni: 5.61e-7
p_wrong: 1.5e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
PDPK1
Tchem
Family: Kinase
Novelty: 0.00422868
p_int: 0.999997992
p_ni: 0.000002008
Data Source: BioPlex
GMEB1
Tbio
Family: TF
Novelty: 0.12195122
p_int: 0.999994638
p_ni: 0.000005362
Score: 0.306
Data Source: BioPlex,STRINGDB
PRDM10
Tbio
Family: TF; Epigenetic
Novelty: 0.00009655
p_int: 0.999985181
p_ni: 0.000014819
Data Source: BioPlex
GMEB2
Tdark
Family: TF
Novelty: 0.2732596
p_int: 0.999984244
p_ni: 0.000015237
p_wrong: 5.19e-7
Score: 0.306
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.02297481
p_int: 0.999968009
p_ni: 0.000031991
Data Source: BioPlex
SNX33
Tbio
Novelty: 0.3156708
p_int: 0.999952833
p_ni: 0.000046983
p_wrong: 1.84e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
SULF1
Tbio
Family: Enzyme
Novelty: 0.01159942
p_int: 0.999944592
p_ni: 0.000055169
p_wrong: 2.39e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  140.06

PubMed score by year
PubTator Score  342.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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