Protein Classes
Protein Summary
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
- ENST00000302190
- ENSP00000307046
- ENSG00000169439
- HSPG1
- HSPG
- CD362
- HSPG1
- SYND2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.99 | ||
small molecule perturbation | 0.92 | ||
microRNA | 0.84 | ||
disease | 0.81 | ||
PubMedID | 0.81 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.06 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.06 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (90)
Reactome (37)
KEGG (4)
PathwayCommons (14)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 37
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Axon guidance | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Axon guidance | ||||
Cell surface interactions at the vascular wall | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Gene Ontology Terms (18)
Functions (2)
Components (7)
Processes (9)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (305)
1 – 10 of 305
DHRS2
Family: Enzyme
Novelty: 0.00319535
p_int: 0.999999758
p_ni: 2.38e-7
p_wrong: 3e-9
Data Source: BioPlex
GPR183
Family: GPCR
Novelty: 0.021257
p_int: 0.999999681
p_ni: 3.18e-7
p_wrong: 1e-9
Data Source: BioPlex
FGF2
Novelty: 0.00009754
p_int: 0.999999424
p_ni: 5.61e-7
p_wrong: 1.5e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
PDPK1
Family: Kinase
Novelty: 0.00422868
p_int: 0.999997992
p_ni: 0.000002008
Data Source: BioPlex
GMEB1
Family: TF
Novelty: 0.12195122
p_int: 0.999994638
p_ni: 0.000005362
Score: 0.306
Data Source: BioPlex,STRINGDB
PRDM10
Family: TF; Epigenetic
Novelty: 0.00009655
p_int: 0.999985181
p_ni: 0.000014819
Data Source: BioPlex
GMEB2
Family: TF
Novelty: 0.2732596
p_int: 0.999984244
p_ni: 0.000015237
p_wrong: 5.19e-7
Score: 0.306
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.02297481
p_int: 0.999968009
p_ni: 0.000031991
Data Source: BioPlex
SNX33
Novelty: 0.3156708
p_int: 0.999952833
p_ni: 0.000046983
p_wrong: 1.84e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
SULF1
Family: Enzyme
Novelty: 0.01159942
p_int: 0.999944592
p_ni: 0.000055169
p_wrong: 2.39e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 140.06
PubMed score by year
PubTator Score 342.18
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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