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Tbio
RNASE4
Ribonuclease 4

Protein Summary
Description
This RNase has marked specificity towards the 3' side of uridine nucleotides. The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397995
  • ENSP00000381081
  • ENSG00000258818
  • ENST00000555597
  • ENSP00000451624
  • ENST00000555835
  • ENSP00000452245

Symbol
  • RNS4
  • RAB1
  • RNS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.98
transcription factor binding site profile
0.91
PubMedID
0.88
small molecule perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribonuclease, RNase A family, 4
703903
Mouse
MGI:1926217
58809
Rat
RGD:61823
56759
Dog
ribonuclease, RNase A family, 4
611048
Cow
ribonuclease A family member 4
VGNC:33998
616089
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribonuclease, RNase A family, 4
Mouse
Rat
Dog
ribonuclease, RNase A family, 4
Cow
ribonuclease A family member 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P34096-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (11)
1 – 10 of 11
RNH1
Tbio
Family: Enzyme
Novelty: 0.00307468
p_int: 0.99999719
p_ni: 1.68e-7
p_wrong: 0.000002642
Data Source: BioPlex
ANG
Tbio
Family: Enzyme
Novelty: 0.00135872
Score: 0.845
Data Source: STRINGDB
RNASE12
Tdark
Family: Enzyme
Novelty: 3
Score: 0.525
Data Source: STRINGDB
RNASE13
Tbio
Family: Enzyme
Novelty: 0.05907604
Score: 0.508
Data Source: STRINGDB
HRG
Tbio
Novelty: 0.0027048
Score: 0.463
Data Source: STRINGDB
ANGPT4
Tbio
Novelty: 0.02566013
Score: 0.456
Data Source: STRINGDB
TPPP3
Tbio
Novelty: 0.08439061
Score: 0.451
Data Source: STRINGDB
TMEM37
Tbio
Family: IC
Novelty: 0.00167645
Score: 0.447
Data Source: STRINGDB
CILP2
Tbio
Novelty: 0.07992715
Score: 0.428
Data Source: STRINGDB
TSEN15
Tbio
Family: Enzyme
Novelty: 0.17606559
Score: 0.424
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.32

PubMed score by year
PubTator Score  18.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer