Tbio GALNS N-acetylgalactosamine-6-sulfatase

Protein Summary

Description

This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P34059
• Q86VK3

Gene Name

• GALNS

Ensembl ID

• ENST00000268695
• ENSP00000268695
• ENSG00000141012

Symbol

• GAS
• MPS4A
• GalN6S
• GALNAC6S

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
histone modification site profile	0.89
kinase perturbation	0.88
transcription factor binding site profile	0.74
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Hydrolase / N-acetylgalactosamine-6-sulfatase

DTO Classes

Protein / Enzyme / Hydrolase / N-acetylgalactosamine-6-sulfatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.64   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.64   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0