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Tbio
MCM7
DNA replication licensing factor MCM7

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replicat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303887
  • ENSP00000307288
  • ENSG00000166508
  • ENST00000343023
  • ENSP00000344006
  • ENST00000354230
  • ENSP00000346171
  • ENST00000621318
  • ENSP00000483795

Symbol
  • CDC47
  • MCM2
  • MCM2
  • CDC47
  • P85MCM
  • P1CDC47
  • PNAS146
  • PPP1R104
  • P1.1-MCM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
1
kinase perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.99
viral protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.69   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 1074   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.69   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 1074   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0