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Tbio
MCM7
DNA replication licensing factor MCM7

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replicat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303887
  • ENSP00000307288
  • ENSG00000166508
  • ENST00000343023
  • ENSP00000344006
  • ENST00000354230
  • ENSP00000346171
  • ENST00000621318
  • ENSP00000483795

Symbol
  • CDC47
  • MCM2
  • MCM2
  • CDC47
  • P85MCM
  • P1CDC47
  • PNAS146
  • PPP1R104
  • P1.1-MCM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
1
kinase perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.99
viral protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.05   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 1074   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.05   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 1074   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (409)
1 – 10 of 409
CCDC88C
Tbio
Novelty:  0.0495648
p_int:  0.999998299
p_ni:  0.000001701
p_wrong:  1e-9
Score:  0.262
Data Source:  BioPlex,STRINGDB
VPS26A
Tbio
Novelty:  0.01804654
p_int:  0.999983391
p_ni:  0.000016609
Score:  0.814
Data Source:  BioPlex,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.999925154
p_ni:  0.000074846
Score:  0.984
Data Source:  BioPlex,STRINGDB
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999632132
p_ni:  0.000367867
Score:  0.999
Data Source:  BioPlex,STRINGDB
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.999420531
p_ni:  0.000579469
Score:  0.819
Data Source:  BioPlex,STRINGDB
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
p_int:  0.998253088
p_ni:  0.001745688
p_wrong:  0.000001224
Score:  0.238
Data Source:  BioPlex,STRINGDB
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.997932062
p_ni:  0.002067938
Score:  0.999
Data Source:  BioPlex,STRINGDB
GINS3
Tbio
Novelty:  0.02892519
p_int:  0.994931709
p_ni:  0.005068291
Score:  0.999
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.992820333
p_ni:  0.007179667
Score:  0.938
Data Source:  BioPlex,STRINGDB
CEP290
Tbio
Novelty:  0.00526375
p_int:  0.983957379
p_ni:  0.002968513
p_wrong:  0.013074108
Score:  0.198
Data Source:  BioPlex,STRINGDB
Pathways (27)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
body height
1
1
1
62.1
1
1
0
1.3
61
1
1
0
1.1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
body height
1
62.1
0
1.3
61
0
1.1
37.6
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 7
VGNC:4422
472460
Macaque
minichromosome maintenance complex component 7
710766
Mouse
MGI:1298398
17220
Rat
RGD:1303018
288532
Dog
minichromosome maintenance complex component 7
VGNC:43087
479737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 7
Macaque
minichromosome maintenance complex component 7
Mouse
Rat
Dog
minichromosome maintenance complex component 7
Publication Statistics
PubMed Score 589.05
PubMed score by year
PubTator Score 190.62
PubTator score by year