You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MCM5
DNA replication licensing factor MCM5

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP. The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216122
  • ENSP00000216122
  • ENSG00000100297

Symbol
  • CDC46
  • CDC46
  • MGORS8
  • P1-CDC46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
transcription factor perturbation
0.98
molecular function
0.95
protein domain
0.85
gene perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.6   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 831   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.6   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 831   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
6.2
chronotype measurement
1
1
1
5.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
6.2
chronotype measurement
1
5.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 5
VGNC:5279
458790
Macaque
minichromosome maintenance complex component 5
717548
Mouse
MGI:103197
17218
Dog
minichromosome maintenance complex component 5
VGNC:43085
610519
Horse
minichromosome maintenance complex component 5
VGNC:20037
100054340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 5
Macaque
minichromosome maintenance complex component 5
Mouse
Dog
minichromosome maintenance complex component 5
Horse
minichromosome maintenance complex component 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P33992-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (384)
1 – 10 of 384
MCMBP
Tbio
Novelty: 0.13330215
p_int: 0.999999383
p_ni: 6.17e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MCM3
Tbio
Novelty: 0.00593382
p_int: 0.999600545
p_ni: 0.000399455
Score: 0.999
Data Source: BioPlex,STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.998736991
p_ni: 0.001263009
Data Source: BioPlex
CAMK2G
Tchem
Family: Kinase
Novelty: 0.04642387
p_int: 0.986840187
p_ni: 0.013159814
Data Source: BioPlex
CEP19
Tbio
Novelty: 0.20749222
p_int: 0.978203576
p_ni: 0.021796424
Data Source: BioPlex
C1QTNF2
Tbio
Novelty: 0.18607978
p_int: 0.969827929
p_ni: 0.030172071
Score: 0.187
Data Source: BioPlex,STRINGDB
GRAMD1B
Tbio
Novelty: 0.2994102
p_int: 0.969574646
p_ni: 0.030423046
p_wrong: 0.000002308
Data Source: BioPlex
NAGK
Tbio
Family: Kinase
Novelty: 0.01603908
p_int: 0.930461373
p_ni: 0.069538627
Score: 0.787
Data Source: BioPlex,STRINGDB
GINS4
Tbio
Novelty: 0.0316194
Score: 0.999
Data Source: STRINGDB
CDT1
Tbio
Novelty: 0.00398013
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.60

PubMed score by year
PubTator Score  99.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer