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Tbio
MCM4
DNA replication licensing factor MCM4

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262105
  • ENSP00000262105
  • ENSG00000104738
  • ENST00000523944
  • ENSP00000430194
  • ENST00000649973
  • ENSP00000496964

Symbol
  • CDC21
  • NKCD
  • CDC21
  • CDC54
  • IMD54
  • NKGCD
  • hCdc21
  • P1-CDC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.99
protein domain
0.97
kinase perturbation
0.91
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.85   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.85   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
74.6
mean reticulocyte volume
1
1
1
53.3
mean corpuscular volume
1
1
1
45.4
eosinophil percentage of leukocytes
1
1
1
22.3
basophil percentage of leukocytes
1
1
1
22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
74.6
mean reticulocyte volume
1
53.3
mean corpuscular volume
1
45.4
eosinophil percentage of leukocytes
1
22.3
basophil percentage of leukocytes
1
22
Pathways (26)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (375)
1 – 10 of 375
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999821544
p_ni: 0.000178456
Score: 0.739
Data Source: BioPlex,STRINGDB
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999761003
p_ni: 0.000238997
Score: 0.907
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.995742401
p_ni: 0.004257599
Score: 0.279
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.995223769
p_ni: 0.004776231
Score: 0.5
Data Source: BioPlex,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.989938038
p_ni: 0.010061962
Score: 0.947
Data Source: BioPlex,STRINGDB
MCM3
Tbio
Novelty: 0.00593382
p_int: 0.98689393
p_ni: 0.01310607
Score: 0.999
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.958363881
p_ni: 0.04163612
Score: 0.441
Data Source: BioPlex,STRINGDB
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.956932814
p_ni: 0.043067185
Score: 0.999
Data Source: BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.94454996
p_ni: 0.05545004
Score: 0.322
Data Source: BioPlex,STRINGDB
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.905817249
p_ni: 0.094182751
Score: 0.351
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  163.85

PubMed score by year
PubTator Score  114.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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