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Tchem
TTK
Dual specificity protein kinase TTK

Protein Summary
Description
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230510
  • ENSP00000230510
  • ENSG00000112742
  • ENST00000369798
  • ENSP00000358813
  • ENST00000509894
  • ENSP00000422936

Symbol
  • MPS1
  • MPS1L1
  • ESK
  • PYT
  • CT96
  • MPH1
  • MPS1
  • MPS1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.91
biological process
0.89
drug perturbation
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.05   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.05   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 760
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (338)
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.999515371
p_ni:  0.000484629
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.998839059
p_ni:  0.001160941
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.988336684
p_ni:  0.011663316
Data Source:  BioPlex
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.984570899
p_ni:  0.015429101
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.963370042
p_ni:  0.036629958
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.960687877
p_ni:  0.039312123
Data Source:  BioPlex
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.958360865
p_ni:  0.041639125
p_wrong:  1e-8
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.93204277
p_ni:  0.06795723
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.893846964
p_ni:  0.106153036
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.89352294
p_ni:  0.10647706
Score:  0.261
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
51.3
anthropometric measurement
1
1
0
1.1
36.6
BMI-adjusted waist circumference
1
2
2
21.6
BMI-adjusted waist-hip ratio
1
1
1
15.1
BMI-adjusted hip circumference
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
51.3
anthropometric measurement
0
1.1
36.6
BMI-adjusted waist circumference
2
21.6
BMI-adjusted waist-hip ratio
1
15.1
BMI-adjusted hip circumference
1
2.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TTK protein kinase
VGNC:3776
462844
Macaque
TTK protein kinase
718430
Mouse
MGI:1194921
22137
Rat
RGD:1305558
315852
Dog
TTK protein kinase
VGNC:47971
481895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TTK protein kinase
Macaque
TTK protein kinase
Mouse
Rat
Dog
TTK protein kinase
Publication Statistics
PubMed Score 272.05
PubMed score by year
PubTator Score 164.34
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title