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Tchem
TTK
Dual specificity protein kinase TTK

Protein Summary
Description
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230510
  • ENSP00000230510
  • ENSG00000112742
  • ENST00000369798
  • ENSP00000358813
  • ENST00000509894
  • ENSP00000422936

Symbol
  • MPS1
  • MPS1L1
  • ESK
  • PYT
  • CT96
  • MPH1
  • MPS1
  • MPS1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.91
biological process
0.89
drug perturbation
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.13   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.13   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 650
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Protein Data Bank (65)
1 – 5 of 65
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (338)
1 – 10 of 338
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.999515371
p_ni: 0.000484629
Data Source: BioPlex
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.998839059
p_ni: 0.001160941
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.988336684
p_ni: 0.011663316
Data Source: BioPlex
ANKRD36B
Tdark
Novelty: 2.44907149
p_int: 0.984570899
p_ni: 0.015429101
Data Source: BioPlex
NPY2R
Tchem
Family: GPCR
Novelty: 0.01177255
p_int: 0.963370042
p_ni: 0.036629958
Data Source: BioPlex
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
p_int: 0.960687877
p_ni: 0.039312123
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.958360865
p_ni: 0.041639125
p_wrong: 1e-8
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.93204277
p_ni: 0.06795723
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.893846964
p_ni: 0.106153036
Data Source: BioPlex
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.89352294
p_ni: 0.10647706
Score: 0.261
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  212.13

PubMed score by year
PubTator Score  164.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer