Tchem TTK Dual specificity protein kinase TTK

Protein Summary

Description

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P33981
• A8K8U5
• B2RDW2
• E1P543
• Q15272
• Q5TCS0
• Q9BW51
• Q9NTM0

Gene Name

• TTK

Ensembl ID

• ENST00000230510
• ENSP00000230510
• ENSG00000112742
• ENST00000369798
• ENSP00000358813
• ENST00000509894
• ENSP00000422936

Symbol

• MPS1
• MPS1L1
• ESK
• PYT
• CT96
• MPH1
• MPS1
• MPS1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.91
biological process	0.89
drug perturbation	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Dual Specificity Protein Kinase Ttk

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Ttk Family / Dual Specificity Protein Kinase Ttk

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.05   (req: < 5)

Gene RIFs: 125   (req: <= 3)

Antibodies: 422   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.05   (req: >= 5)

Gene RIFs: 125   (req: > 3)

Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 760

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1