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Tbio
KDELR2
ER lumen protein-retaining receptor 2

Protein Summary
Description
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258739
  • ENSP00000258739
  • ENSG00000136240
  • ENST00000490996
  • ENSP00000420501

Symbol
  • ERD2.2
  • ELP-1
  • ERD2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
transcription factor perturbation
0.8
small molecule perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
3
4
94.3
red blood cell distribution width
2
2
2
84.6
mean platelet volume
3
1
3
82.9
neutrophil percentage of leukocytes
2
2
2
72
lymphocyte percentage of leukocytes
2
2
2
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
94.3
red blood cell distribution width
2
84.6
mean platelet volume
3
82.9
neutrophil percentage of leukocytes
2
72
lymphocyte percentage of leukocytes
2
67.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KDEL endoplasmic reticulum protein retention receptor 2
704335
Mouse
MGI:1914163
66913
Rat
RGD:1304618
304290
Dog
KDEL endoplasmic reticulum protein retention receptor 2
VGNC:42315
612839
Horse
KDEL endoplasmic reticulum protein retention receptor 2
VGNC:19329
102150227
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KDEL endoplasmic reticulum protein retention receptor 2
Mouse
Rat
Dog
KDEL endoplasmic reticulum protein retention receptor 2
Horse
KDEL endoplasmic reticulum protein retention receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P33947-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (208)
1 – 10 of 208
SCARB1
Tchem
Novelty: 0.00087703
p_int: 0.908616639
p_ni: 0.091383361
Data Source: BioPlex
ATG9A
Tbio
Novelty: 0.01995033
p_int: 0.902916527
p_ni: 0.097080139
p_wrong: 0.000003334
Data Source: BioPlex
GLRB
Tclin
Family: IC
Novelty: 0.01721113
p_int: 0.862217215
p_ni: 0.011981735
p_wrong: 0.12580105
Data Source: BioPlex
COPB1
Tbio
Novelty: 0.0078407
Score: 0.978
Data Source: STRINGDB
SURF4
Tbio
Novelty: 0.03230108
Score: 0.965
Data Source: STRINGDB
TMED10
Tbio
Novelty: 0.02742083
Score: 0.96
Data Source: STRINGDB
ARF4
Tbio
Family: Enzyme
Novelty: 0.01166211
Score: 0.95
Data Source: STRINGDB
COPZ1
Tbio
Novelty: 0.01405958
Score: 0.942
Data Source: STRINGDB
SEC22B
Tbio
Novelty: 0.03035448
Score: 0.939
Data Source: STRINGDB
COPG1
Tbio
Novelty: 0.01331193
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.38

PubMed score by year
PubTator Score  4.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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