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Tbio
HIST1H2BB
Histone H2B type 1-B

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615966
  • ENSP00000482674
  • ENSG00000276410

Symbol
  • H2BFF
  • H2B.1
  • H2B/f
  • H2BFF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
kinase
0.9
interacting protein
0.88
cell type or tissue
0.85
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (64)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
10
99.6
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
mean corpuscular hemoglobin concentration
10
5
15
99.1
mean corpuscular volume
5
5
8
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.6
hemoglobin measurement
7
99.4
hematocrit
10
99.3
mean corpuscular hemoglobin concentration
15
99.1
mean corpuscular volume
8
99
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33778-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 89
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (417)
1 – 10 of 417
H2AFJ
Tbio
Novelty:  0.34726304
Score:  0.997
Data Source:  STRINGDB
HIST1H2AA
Tbio
Novelty:  0.04021488
Score:  0.987
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.984
Data Source:  STRINGDB
HIST1H2AH
Tbio
Novelty:  0.09573052
Score:  0.983
Data Source:  STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
Score:  0.981
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.981
Data Source:  STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.98
Data Source:  STRINGDB
HIST3H2A
Tbio
Novelty:  0.34036249
Score:  0.979
Data Source:  STRINGDB
HIST1H2AD
Tdark
Novelty:  0.90754234
Score:  0.977
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.977
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.23

PubMed score by year
PubTator Score  4.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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