Tbio CKS2 Cyclin-dependent kinases regulatory subunit 2

Protein Summary

Description

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33552
• Q6FGI9
• Q6LET5
• CKS-2

Gene Name

• CKS2

Ensembl ID

• ENST00000314355
• ENSP00000364976
• ENSG00000123975

Symbol

• CKSHS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor binding site profile	0.93
gene perturbation	0.83
co-expressed gene	0.79
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Cyclin-dependent Kinases Regulatory Subunit 2

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Cyclin-dependent Kinases Regulatory Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.61   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.61   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0