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Tbio
CKS2
Cyclin-dependent kinases regulatory subunit 2

Protein Summary
Description
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314355
  • ENSP00000364976
  • ENSG00000123975

Symbol
  • CKSHS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor binding site profile
0.93
gene perturbation
0.83
co-expressed gene
0.79
disease perturbation
0.79


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.76   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.76   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC28 protein kinase regulatory subunit 2
VGNC:4663
464582
Mouse
MGI:1913447
66197
Rat
RGD:1562047
498709
Dog
CDC28 protein kinase regulatory subunit 2
VGNC:39293
100686141
Cow
CDC28 protein kinase regulatory subunit 2
VGNC:27388
767985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC28 protein kinase regulatory subunit 2
Mouse
Rat
Dog
CDC28 protein kinase regulatory subunit 2
Cow
CDC28 protein kinase regulatory subunit 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (265)
1 – 10 of 265
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999865
p_ni: 1.35e-7
Score: 0.973
Data Source: BioPlex,STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
p_int: 0.999997122
p_ni: 0.000002878
Score: 0.997
Data Source: BioPlex,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
p_int: 0.999992419
p_ni: 0.000007576
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999982071
p_ni: 0.000017929
Score: 0.873
Data Source: BioPlex,STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
p_int: 0.999940517
p_ni: 0.000059475
p_wrong: 8e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
CAMK1D
Tchem
Family: Kinase
Novelty: 0.0274233
p_int: 0.999896638
p_ni: 0.000103358
p_wrong: 5e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999891004
p_ni: 0.000108706
p_wrong: 2.9e-7
Score: 0.73
Data Source: BioPlex,STRINGDB
CDT1
Tbio
Novelty: 0.00398013
p_int: 0.999885365
p_ni: 0.000114596
p_wrong: 3.9e-8
Score: 0.911
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.76

PubMed score by year
PubTator Score  29.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer