You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ABCC1
Multidrug resistance-associated protein 1

Protein Summary
Description
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399410
  • ENSP00000382342
  • ENSG00000103222
  • ENST00000621144
  • ENSP00000483316
  • ENSG00000278183

Symbol
  • MRP
  • MRP1
  • MRP
  • ABCC
  • GS-X
  • MRP1
  • ABC29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
0.98
protein domain
0.92
disease
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.34   (req: < 5)
Gene RIFs: 322   (req: <= 3)
Antibodies: 557   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.34   (req: >= 5)
Gene RIFs: 322   (req: > 3)
Antibodies: 557   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4