Tchem ABCC1 Multidrug resistance-associated protein 1

Protein Summary

Description

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P33527
• A3RJX2
• C9JPJ4
• O14819
• O43333
• P78419
• Q59GI9
• Q9UQ97
• Q9UQ99
• Q9UQA0

Gene Name

• ABCC1

Ensembl ID

• ENST00000399410
• ENSP00000382342
• ENSG00000103222
• ENST00000621144
• ENSP00000483316
• ENSG00000278183

Symbol

• MRP
• MRP1
• MRP
• ABCC
• GS-X
• MRP1
• ABC29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
drug	1
molecular function	0.98
protein domain	0.92
disease	0.9

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Multidrug Resistance-associated Protein 1

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Multidrug Resistance-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.34   (req: < 5)

Gene RIFs: 330   (req: <= 3)

Antibodies: 557   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.34   (req: >= 5)

Gene RIFs: 330   (req: > 3)

Antibodies: 557   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4