You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GUCY1A2
Guanylate cyclase soluble subunit alpha-2

Protein Summary
Description
Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282249
  • ENSP00000282249
  • ENSG00000152402
  • ENST00000347596
  • ENSP00000344874
  • ENST00000526355
  • ENSP00000431245

Symbol
  • GUC1A2
  • GUCSA2
  • GC-SA2
  • GUC1A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
trait
0.86
protein domain
0.85
gene perturbation
0.73
biological process
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.19   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.19   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 2
VGNC:11801
466769
Macaque
guanylate cyclase 1 soluble subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:4684]
Mouse
MGI:2660877
234889
Rat
RGD:621655
66012
Dog
guanylate cyclase 1 soluble subunit alpha 2
VGNC:41566
479455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 1 soluble subunit alpha 2
Macaque
guanylate cyclase 1 soluble subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:4684]
Mouse
Rat
Dog
guanylate cyclase 1 soluble subunit alpha 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P33402-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Muscle contraction
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Hemostasis
Muscle contraction
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Smooth Muscle Contraction
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
p_int:  1
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.919
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.918
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.904
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
PDE1A
Tclin
Family:  Enzyme
Novelty:  0.02694265
Score:  0.856
Data Source:  STRINGDB
PDE2A
Tclin
Family:  Enzyme
Novelty:  0.00862513
Score:  0.832
Data Source:  STRINGDB
GUCY1A1
Tclin
Family:  Enzyme
Novelty:  0.02289791
Score:  0.82
Data Source:  STRINGDB
PDE9A
Tchem
Family:  Enzyme
Novelty:  0.01862532
Score:  0.813
Data Source:  STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
Score:  0.808
Data Source:  STRINGDB
Publication Statistics
PubMed Score  19.19

PubMed score by year
PubTator Score  0.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer