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Tchem
DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Protein Summary
Description
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331200
  • ENSP00000370376
  • ENSG00000128951
  • ENST00000455976
  • ENSP00000405160

Symbol
  • dUTPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
co-expressed gene
0.96
transcription factor perturbation
0.96
virus perturbation
0.94
kinase perturbation
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.58   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 402.58   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (326)
TYMS
Tclin
Family:  Enzyme
Novelty:  0.00087522
Score:  0.999
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.994
Data Source:  STRINGDB
DCTD
Tbio
Family:  Enzyme
Novelty:  0.02275597
Score:  0.978
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.978
Data Source:  STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
Score:  0.977
Data Source:  STRINGDB
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
Score:  0.975
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.967
Data Source:  STRINGDB
TK1
Tchem
Family:  Kinase
Novelty:  0.00139343
Score:  0.965
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.963
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.958
Data Source:  STRINGDB
Pathways (10)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
71.4
BMI-adjusted waist circumference
2
2
2
58.3
lymphocyte percentage of leukocytes
1
1
1
51.7
spontaneous coronary artery dissection
1
1
0
1.8
33.1
body height
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
71.4
BMI-adjusted waist circumference
2
58.3
lymphocyte percentage of leukocytes
1
51.7
spontaneous coronary artery dissection
0
1.8
33.1
body height
1
27.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 402.58
PubMed score by year
PubTator Score 35.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title