Tbio LSP1 Lymphocyte-specific protein 1

Protein Summary

Description

May play a role in mediating neutrophil activation and chemotaxis. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33241
• B3KPP1
• B3KRR6
• E9PBV6
• E9PFP3
• Q16096
• Q53H48
• Q6FHM3
• Q9BUY8

Gene Name

• LSP1

Ensembl ID

• ENST00000311604
• ENSP00000308383
• ENSG00000130592
• ENST00000381775
• ENSP00000371194
• ENST00000405957
• ENSP00000383932
• ENST00000406638
• ENSP00000384022
• ENST00000612798
• ENSP00000484140

Symbol

• WP34
• WP34
• pp52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.9
gene perturbation	0.74
drug perturbation	0.71
transcription factor	0.7
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.25   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.25   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0