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Tbio
LSP1
Lymphocyte-specific protein 1

Protein Summary
Description
May play a role in mediating neutrophil activation and chemotaxis. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311604
  • ENSP00000308383
  • ENSG00000130592
  • ENST00000381775
  • ENSP00000371194
  • ENST00000405957
  • ENSP00000383932
  • ENST00000406638
  • ENSP00000384022
  • ENST00000612798
  • ENSP00000484140

Symbol
  • WP34
  • WP34
  • pp52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.9
gene perturbation
0.74
drug perturbation
0.71
transcription factor
0.7
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.88   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.88   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.1
92.3
diastolic blood pressure
2
3
3
75.5
1
3
3
65.8
Diuretic use measurement
1
1
1
58.2
Calcium channel blocker use measurement
1
1
1
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.3
diastolic blood pressure
3
75.5
3
65.8
Diuretic use measurement
1
58.2
Calcium channel blocker use measurement
1
57.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96832
16985
Rat
RGD:1306133
361680
Dog
lymphocyte specific protein 1
VGNC:42849
611553
Cow
lymphocyte specific protein 1
VGNC:31063
508832
Chicken
lymphocyte-specific protein 1
CGNC:4964
374254
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
lymphocyte specific protein 1
Cow
lymphocyte specific protein 1
Chicken
lymphocyte-specific protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33241-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (78)
1 – 10 of 78
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999959954
p_ni: 0.000040046
Data Source: BioPlex
SCIN
Tbio
Novelty: 0.0080322
p_int: 0.999458806
p_ni: 0.000488186
p_wrong: 0.000053008
Score: 0.821
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.99944983
p_ni: 0.00055017
Data Source: BioPlex
GSN
Tbio
Novelty: 0.00060852
p_int: 0.998690372
p_ni: 0.001309628
Score: 0.803
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.997895979
p_ni: 0.002104021
Data Source: BioPlex
TMOD2
Tbio
Novelty: 0.10324176
p_int: 0.991284549
p_ni: 0.008715451
Score: 0.737
Data Source: BioPlex,STRINGDB
CAPN2
Tchem
Novelty: 0.00431673
p_int: 0.978914515
p_ni: 0.021085485
Score: 0.188
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.974004026
p_ni: 0.025995974
Data Source: BioPlex
LIMA1
Tbio
Novelty: 0.02718476
p_int: 0.908435677
p_ni: 0.091564323
Score: 0.158
Data Source: BioPlex,STRINGDB
MYO1B
Tbio
Novelty: 0.00761267
p_int: 0.853529946
p_ni: 0.146470054
Score: 0.272
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  117.88

PubMed score by year
PubTator Score  71.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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