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Tbio
CSTF2
Cleavage stimulation factor subunit 2

Protein Summary
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372972
  • ENSP00000362063
  • ENSG00000101811

Symbol
  • CstF-64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.84
disease perturbation
0.83
interacting protein
0.69
transcription factor binding site profile
0.6


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.74   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.74   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 2
VGNC:10175
473699
Macaque
cleavage stimulation factor subunit 2
701235
Mouse
MGI:1343054
108062
Rat
RGD:1596566
683927
Dog
cleavage stimulation factor subunit 2
VGNC:39683
492015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 2
Macaque
cleavage stimulation factor subunit 2
Mouse
Rat
Dog
cleavage stimulation factor subunit 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33240-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (296)
1 – 10 of 296
CSTF2T
Tbio
Novelty: 0.11811814
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.837264735
p_ni: 0.162735262
p_wrong: 3e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.815801947
p_ni: 0.184198053
Data Source: BioPlex
CPEB1
Tbio
Novelty: 0.00444378
p_int: 0.791172938
p_ni: 0.208827061
Score: 0.89
Data Source: BioPlex,STRINGDB
CSTF3
Tbio
Novelty: 0.05260909
Score: 0.999
Data Source: Reactome,STRINGDB
SYMPK
Tbio
Novelty: 0.01773552
Score: 0.998
Data Source: STRINGDB
CPSF3
Tchem
Novelty: 0.01880576
Score: 0.998
Data Source: STRINGDB
CSTF1
Tbio
Novelty: 0.08711712
Score: 0.998
Data Source: Reactome,STRINGDB
CPSF2
Tbio
Novelty: 0.0510853
Score: 0.998
Data Source: STRINGDB
CPSF1
Tbio
Novelty: 0.04396897
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.74

PubMed score by year
PubTator Score  38.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer