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Tbio
KIF5B
Kinesin-1 heavy chain

Protein Summary
Description
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302418
  • ENSP00000307078
  • ENSG00000170759

Symbol
  • KNS
  • KNS1
  • KNS
  • KINH
  • KNS1
  • UKHC
  • HEL-S-61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
hub protein
0.94
disease perturbation
0.9
transcription factor perturbation
0.8
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.76   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 443   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.76   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 443   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0