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Tbio
KIF5B
Kinesin-1 heavy chain

Protein Summary
Description
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302418
  • ENSP00000307078
  • ENSG00000170759

Symbol
  • KNS
  • KNS1
  • KNS
  • KINH
  • KNS1
  • UKHC
  • HEL-S-61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
hub protein
0.94
disease perturbation
0.9
transcription factor perturbation
0.8
microRNA
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.96   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 443   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.96   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 443   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 5B
VGNC:4724
450390
Macaque
kinesin family member 5B
696652
Mouse
MGI:1098268
16573
Rat
RGD:621559
117550
Dog
kinesin family member 5B
VGNC:42408
100855651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 5B
Macaque
kinesin family member 5B
Mouse
Rat
Dog
kinesin family member 5B
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33176-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (38)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (280)
1 – 10 of 280
KLC1
Tbio
Novelty: 0.00653484
p_int: 0.999972789
p_ni: 0.000027211
Score: 0.998
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.999871335
p_ni: 0.000128665
Data Source: BioPlex
SYNE4
Tbio
Novelty: 0.0739848
p_int: 0.999774657
p_ni: 0.000225343
Score: 0.694
Data Source: BioPlex,STRINGDB
COG6
Tbio
Novelty: 0.02874093
p_int: 0.999116951
p_ni: 0.000883048
Score: 0.223
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.997863753
p_ni: 0.002136247
Data Source: BioPlex
TRIP6
Tbio
Novelty: 0.02183202
p_int: 0.997239803
p_ni: 0.002760197
Score: 0.18
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.997168025
p_ni: 0.002831975
Score: 0.177
Data Source: BioPlex,STRINGDB
TRAK2
Tbio
Novelty: 0.04192075
p_int: 0.990013529
p_ni: 0.009986463
p_wrong: 8e-9
Score: 0.887
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.98686137
p_ni: 0.01313863
Score: 0.201
Data Source: BioPlex,STRINGDB
AZIN1
Tbio
Family: Enzyme
Novelty: 0.03017595
p_int: 0.946192793
p_ni: 0.053807207
Score: 0.679
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  167.96

PubMed score by year
PubTator Score  130.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer