Tbio CDH5 Cadherin-5

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P33151
• Q4VAI5
• Q4VAI6

Gene Name

• CDH5

Ensembl ID

• ENST00000341529
• ENSP00000344115
• ENSG00000179776
• ENST00000614547
• ENSP00000479381
• ENST00000649567
• ENSP00000497290

Symbol

• 7B4
• CD144

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.85
protein domain	0.85
tissue sample	0.74
gene perturbation	0.67
microRNA	0.67

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.27   (req: < 5)

Gene RIFs: 187   (req: <= 3)

Antibodies: 1071   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.27   (req: >= 5)

Gene RIFs: 187   (req: > 3)

Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2	2	2		21.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2		21.3

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cadherin 5	VGNC:8964	467991
Macaque	cadherin 5		693297
Mouse	cadherin 5	MGI:105057	12562
Rat	cadherin 5	RGD:1307370	307618
Dog	cadherin 5	VGNC:39033	489775

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cadherin 5
Macaque	cadherin 5
Mouse	cadherin 5
Rat	cadherin 5
Dog	cadherin 5

Pathways (87)

Reactome (9)

KEGG (3)

PathwayCommons (4)

WikiPathways (71)

Adherens junctions interactions (R-HSA-418990)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (28)

Functions (7)

Components (9)

Processes (12)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (293)

Explore Interacting Targets

1 – 10 of 293

• See Interactions on String-DB

ARVCF

Tbio

Novelty: 0.03248592

p_int: 0.9999996

p_ni: 3.99e-7

p_wrong: 1e-9

Score: 0.413

Data Source: BioPlex,STRINGDB

PKP4

Tbio

Novelty: 0.03654703

p_int: 0.999998964

p_ni: 0.000001035

p_wrong: 1e-9

Score: 0.628

Data Source: BioPlex,STRINGDB

SCML1

Tdark

Novelty: 0.60106322

p_int: 0.999984618

p_ni: 0.000007986

p_wrong: 0.000007396

Data Source: BioPlex

CTNNA2

Tbio

Novelty: 0.00783865

p_int: 0.999967386

p_ni: 0.000032614

Score: 0.27

Data Source: BioPlex,STRINGDB

CTNNB1

Tchem

Novelty: 0.0000744

p_int: 0.999923201

p_ni: 0.000076799

Score: 0.988

Data Source: BioPlex,STRINGDB

RBFA

Tbio

Novelty: 0.1061138

p_int: 0.999695281

p_ni: 0.000166668

p_wrong: 0.000138051

Data Source: BioPlex

CTNNA1

Tbio

Novelty: 0.00925774

p_int: 0.999673601

p_ni: 0.000326399

Score: 0.95

Data Source: BioPlex,Reactome,STRINGDB

SARAF

Tbio

Novelty: 0.0383833

p_int: 0.999653218

p_ni: 0.000345354

p_wrong: 0.000001429

Data Source: BioPlex

PLD1

Tchem

Family: Enzyme

Novelty: 0.00608142

p_int: 0.999629784

p_ni: 0.000370216

Data Source: BioPlex

TMTC3

Tdark

Novelty: 0.17411457

p_int: 0.999628636

p_ni: 0.000371233

p_wrong: 1.32e-7

Score: 0.187

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1341.27

PubMed score by year

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PubTator Score  755.43

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane

GWAS Trait Find Similar Targets

reticulocyte count

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype