Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five ...more
- ENST00000341529
- ENSP00000344115
- ENSG00000179776
- ENST00000614547
- ENSP00000479381
- ENST00000649567
- ENSP00000497290
- 7B4
- CD144
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.85 | ||
protein domain | 0.85 | ||
tissue sample | 0.74 | ||
gene perturbation | 0.67 | ||
microRNA | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1381.88 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 1071 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1381.88 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 1071 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (293)
ARVCF
Novelty: 0.03248592
p_int: 0.9999996
p_ni: 3.99e-7
p_wrong: 1e-9
Score: 0.413
Data Source: BioPlex,STRINGDB
PKP4
Novelty: 0.03654703
p_int: 0.999998964
p_ni: 0.000001035
p_wrong: 1e-9
Score: 0.628
Data Source: BioPlex,STRINGDB
SCML1
Novelty: 0.60106322
p_int: 0.999984618
p_ni: 0.000007986
p_wrong: 0.000007396
Data Source: BioPlex
CTNNA2
Novelty: 0.00783865
p_int: 0.999967386
p_ni: 0.000032614
Score: 0.27
Data Source: BioPlex,STRINGDB
CTNNB1
Novelty: 0.0000744
p_int: 0.999923201
p_ni: 0.000076799
Score: 0.988
Data Source: BioPlex,STRINGDB
RBFA
Novelty: 0.1061138
p_int: 0.999695281
p_ni: 0.000166668
p_wrong: 0.000138051
Data Source: BioPlex
CTNNA1
Novelty: 0.00925774
p_int: 0.999673601
p_ni: 0.000326399
Score: 0.95
Data Source: BioPlex,Reactome,STRINGDB
SARAF
Novelty: 0.0383833
p_int: 0.999653218
p_ni: 0.000345354
p_wrong: 0.000001429
Data Source: BioPlex
PLD1
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999629784
p_ni: 0.000370216
Data Source: BioPlex
TMTC3
Novelty: 0.17411457
p_int: 0.999628636
p_ni: 0.000371233
p_wrong: 1.32e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (87)
Reactome (9)
KEGG (3)
PathwayCommons (4)
WikiPathways (71)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (7)
Components (9)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 2 | 2 | 2 | 50.6 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte count | 2 | 50.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cadherin 5 | VGNC:8964 | 467991 | |||||
Macaque | cadherin 5 | 693297 | ||||||
Mouse | MGI:105057 | 12562 | ||||||
Rat | RGD:1307370 | 307618 | ||||||
Dog | cadherin 5 | VGNC:39033 | 489775 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cadherin 5 | |||||
Macaque | cadherin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 5 | |||||
Publication Statistics
PubMed Score 1381.88
PubMed score by year
PubTator Score 755.43
PubTator score by year
Related Publications
Text Mined References (220)
GeneRif Annotations (187)
Items per page:
0 of 0
PMID | Year | Title |
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