ACSL1
Long-chain-fatty-acid--CoA ligase 1
Protein Summary
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
- ENST00000281455
- ENSP00000281455
- ENSG00000151726
- ENST00000504342
- ENSP00000425006
- ENST00000513317
- ENSP00000426150
- ENST00000515030
- ENSP00000422607
- FACL1
- FACL2
- LACS
- LACS1
- LACS2
- ACS1
- LACS
- FACL1
- FACL2
- LACS1
- LACS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.96 | ||
cellular component | 0.92 | ||
disease perturbation | 0.87 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 400.36 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 277 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 400.36 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 277 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0